{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:18:22Z","timestamp":1768817902837,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. This prospective study investigated the efficacy of a gonadotropin-releasing hormone agonist (LH-RHa) in restoring defective mini-puberty.<jats:italic> Materials and Methods<\/jats:italic>. Boys with isolated bilateral cryptorchidism and defective mini-puberty were randomly divided into two groups. The \u201csurgery only\u201d group underwent a second orchidopexy without hormonal treatment (control). The \u201cLH-RHa\u201d group received LH-RHa therapy followed by a second orchidopexy. The number of Ad spermatogonia and the total germ cell count per tubule (S\/T) were analyzed.<jats:italic> Results<\/jats:italic>. Five boys were included in each arm. In the LH-RHa group, the median S\/T increased from 0.11 to 0.42, p=0.04. In the surgery only group, the median S\/T did not change. In the surgery only group, none of the testes had Ad spermatogonia. In contrast, in the LH-RHa group, all testes completed the transition from gonocytes to Ad spermatogonia (p=0.008).<jats:italic> Conclusions<\/jats:italic>. Treatment with LH-RHa was effective in rescuing defective mini-puberty in boys with bilateral cryptorchidism.<\/jats:p>","DOI":"10.1155\/2018\/4651218","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T19:45:02Z","timestamp":1530647102000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-1352","authenticated-orcid":true,"given":"Beata","family":"Vincel","sequence":"first","affiliation":[{"name":"Children\u2019s Surgery Centre, Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, 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