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We previously demonstrated that administration of exogenous antioxidants (<jats:italic>N<\/jats:italic>\u2010acetylcysteine and trolox) reduces CASQ1\u2010null mortality during exposure to heat. As aerobic training is known to boost endogenous antioxidant protection, we subjected CASQ1\u2010null mice to treadmill running for 2 months at 60% of their maximal speed for 1\u2009h, 5 times\/week. When exposed to heat stress protocol (41\u00b0C\/1\u2009h), the mortality rate of CASQ1\u2010null mice was significantly reduced compared to untrained animals (86% versus 16%). Protection from heatstrokes was accompanied by a reduced increase in core temperature during the stress protocol and by an increased threshold of response to caffeine of isolated <jats:italic>extensor digitorum longus<\/jats:italic> muscles during <jats:italic>in vitro<\/jats:italic> contracture test. At cellular and molecular levels, aerobic training (i) improved mitochondrial function while reducing their damage and (ii) lowered calpain activity and lipid peroxidation in membranes isolated from sarcoplasmic reticulum and mitochondria. Based on this evidence, we hypothesize that the protective effect of aerobic training is essentially mediated by a reduction in oxidative stress during exposure of CASQ1\u2010null mice to adverse environmental conditions.<\/jats:p>","DOI":"10.1155\/2018\/4652480","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T23:31:17Z","timestamp":1522798277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aerobic Training Prevents Heatstrokes in Calsequestrin\u20101 Knockout Mice by Reducing Oxidative Stress"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-878X","authenticated-orcid":false,"given":"Fl\u00e1via 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