{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:37:45Z","timestamp":1784176665940,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital Public Health Project","award":["Z131100006813036"],"award-info":[{"award-number":["Z131100006813036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2018,7,16]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Post-TIPS hepatic encephalopathy (PSE) is a complex process involving numerous risk factors; the root cause is unclear, but an elevation of blood ammonia due to portosystemic shunt and metabolic disorders in hepatocytes has been proposed as an important risk factor.<jats:italic>Aims.<\/jats:italic>The aim of this study was to investigate the impact of pathological features of mitochondrial ultrastructure on PSE via transjugular liver biopsy at TIPS implantation.<jats:italic>Methods<\/jats:italic>. We evaluated the pathological damage of mitochondrial ultrastructure on recruited patients by the Flameng classification system. A score \u22642 (no or low damage) was defined as group A, and a score &gt;2 (high damage level) was defined as group B; routine follow-up was required at 1 and 2 years; the incidence of PSE and multiple clinical data were recorded.<jats:italic>Results.<\/jats:italic>A total of 78 cases in group A and 42 in group B completed the study. The incidence of PSE after 1 and 2 years in group B (35.7% and 45.2%, respectively) was significantly higher than that in group A (16.7% and 24.4%, respectively); the 1- and 2-year OR (95% CI) were 2.778 (1.166-6.615) and 2.565 (1.155-5.696), respectively, for groups A and B. Importantly, group B had worse incidence of PSE than group A [P=0.014, hazard ratio (95%CI): 2.172 (1.190-4.678)].<jats:italic>Conclusion<\/jats:italic>. Aggressive damage to mitochondrial ultrastructure in liver shunt predicts susceptibility to PSE. The registration number is<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02540382\">NCT02540382<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2018\/4671590","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T23:31:12Z","timestamp":1531783872000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Pathological Features of Mitochondrial Ultrastructure Predict Susceptibility to Post-TIPS Hepatic Encephalopathy"],"prefix":"10.1155","volume":"2018","author":[{"given":"Hong-bin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-dong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy, Beijing Shijitan Hospital, Capital 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