{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:43Z","timestamp":1792084123618,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":209,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>We present a case of a 39\u2010year\u2010old G8P6 Pacific Islander woman who at 15+5 weeks\u2019 gestation had an out\u2010of\u2010hospital cardiac arrest secondary to profound hypokalaemia which was associated with severe hyperemesis gravidarum (HG). Her clinical course after arrest was complicated by a second 5\u2010minute cardiac arrest in the Intensive Care Unit (ICU) (pre\u2010arrest potassium 1.8), anuric renal failure requiring dialysis, ischaemic hepatitis, and encephalopathy and unfortunately fetal demise and a spontaneous miscarriage on day 2 of admission. Despite these complications, she was discharged home 4 weeks later with a full recovery. Following a plethora of inpatient and outpatient investigations, the cause of her cardiac arrest was determined to be profound hypokalaemia. The hypokalaemia was presumed second to a perfect storm of HG with subsequent nutritional deficiencies causing electrolyte wasting, extracellular fluid (ECF) volume reduction, and activation of the renin\u2010angiotensin\u2010aldosterone axis (RAAS). This combined with the physiological changes that promote potassium wasting in pregnancy including volume expansion, increased renal blood flow, increased glomerular filtration rate, and increase in cortisol contributed to the patient having a profoundly low total body potassium level. This diagnosis is further strengthened by the fact that her pre\u2010 and post\u2010pregnancy potassium levels were within normal limits in the absence of supplementary potassium. This case highlights the potentially life\u2010threatening electrolyte imbalances that can occur with HG and the importance of recognising the disease, comprehensive electrolyte monitoring, and aggressive management in pregnancy.<\/jats:p>","DOI":"10.1155\/2018\/4687587","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T19:31:01Z","timestamp":1532892661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Profound Hypokalaemia Resulting in Maternal Cardiac Arrest: A Catastrophic Complication of Hyperemesis Gravidarum?"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-9282","authenticated-orcid":false,"given":"Anna","family":"Walch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Duke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Auty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audris","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,29]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00552.x"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.02.012"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.05.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.21767\/2471-8165.1000025"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2407607"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040414"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309598"},{"key":"e_1_2_6_8_2","article-title":"Mortality secondary to hyperemesis gravidarum: a case report","volume":"6","author":"MacGibbon K. 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