{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:44:59Z","timestamp":1788536699900,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371725"],"award-info":[{"award-number":["81371725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To clarify the association between the single nucleotide polymorphisms (SNPs) in the<jats:italic> NLRP1<\/jats:italic> and<jats:italic> NLRP3<\/jats:italic> and Psoriasis Vulgaris (PsV) in the Chinese Han population.<jats:italic> Methods<\/jats:italic>. We genotyped eight SNPs, four from<jats:italic> NLRP1<\/jats:italic> (rs8079034, rs11651270, rs11657747, and rs878329) and<jats:italic> NLRP3<\/jats:italic> (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls in the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and haplotype frequencies were analyzed using a case-control study design.<jats:italic> Results<\/jats:italic>. We identified two SNPs, rs3806265 and rs10754557, in<jats:italic> NLRP3<\/jats:italic> that were significantly associated with PsV. The genotype distribution of the rs3806265 SNP was significantly different between cases and controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0451<\/mml:mn><\/mml:math>; OR = 0.791; 95% CI = 0.627\u20130.998). In the recessive model, the genotype distribution of the rs10754557 SNP was significantly different between cases and controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0344<\/mml:mn><\/mml:math>; OR = 1.277; 95% CI = 0.987\u20131.652). The haplotype analysis of rs3806265 and rs10754557 also presented a significant association of TA haplotype with PsV (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">4.529<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.033<\/mml:mn><\/mml:math>).<jats:italic> Conclusion<\/jats:italic>. NLRP3 may play a role in PsV susceptibility in the Chinese Han population.<\/jats:p>","DOI":"10.1155\/2018\/4714836","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T19:31:19Z","timestamp":1522783879000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Association of<i> NLRP1<\/i> and<i> NLRP3<\/i> Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-6651","authenticated-orcid":true,"given":"Pei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-6556","authenticated-orcid":true,"given":"Yuzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29849"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0539-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125369"},{"key":"4","volume":"8","year":"2017","journal-title":"Nature Communications"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210021"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9547902"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/846782"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13178"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01070.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.370"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12049"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101787"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-14"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/art.33370"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4238\/2015.October.29.17"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.168"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.01008.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.025"},{"key":"21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ng.690","volume":"42","year":"2010","journal-title":"Nature Genetics"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01163-y"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003703"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.269"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.04.014"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/art.23604"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/4714836.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/4714836.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/4714836.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T18:18:14Z","timestamp":1522952294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/4714836\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":26,"alternative-id":["4714836","4714836"],"URL":"https:\/\/doi.org\/10.1155\/2018\/4714836","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}