{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:09:07Z","timestamp":1792084147734,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Amhara Regional Health Bureau"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2018,7,18]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Enterococci are becoming the most important public health concern and emerging as multidrug-resistant organisms around the world including Africa particularly in Ethiopia where there is a lack of availability of effective antimicrobial drugs. However, there is a paucity of data on the prevalence and associated risk factors of vancomycin-resistant enterococci in Ethiopia.\n                    <jats:italic>Objective<\/jats:italic>\n                    . This study was aimed to assess the prevalence of vancomycin-resistant enterococci and its associated risk factors among HIV-positive and -negative clients.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A comparative cross-sectional study was conducted from February to May, 2017, on 300 participants at Dessie Referral Hospital. Data were gathered using a pretested structured questionnaire, stool samples were collected and inoculated on to bile esculin agar, and presumptive colonies were inoculated in brain-heart infusion broth containing 6.5% NaCl for selective identification of enterococci. Antibiotic susceptibility tests were done using the Kirby\u2013Bauer disk diffusion method. Data were analyzed using SPSS version 22 software package.\n                    <jats:italic>Results<\/jats:italic>\n                    . A total of 300 study participants were enrolled in this study, of which 57.7% were females with a mean age of 34.4, a range of 19\u201373 years. The overall prevalence of enterococci was 37.3%. The prevalence of VRE was 6.3%. From all isolates, the prevalence of VRE among HIV-positive and -negative clients was 5.9% and 7.4%, respectively. Resistance gentamicin, ampicillin, penicillin, and erythromycin was 37.5%, 34.8%, 34.8%, and 22.3%, respectively. Prevalence of multidrug resistance was (29.5%). Being low in hemoglobin content was significantly associated with VRE.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The high prevalence of VRE and multidrug-resistant enterococci in this study signals the emergence of VRE. Detection of VRE in this study indicates decreased antibiotic treatment options of multidrug-resistant enterococci. Therefore, there should be a need to perform continuous surveillance, rational use of antibiotics, and more detailed study using phenotypic and genotypic methods.\n                  <\/jats:p>","DOI":"10.1155\/2018\/4753460","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T20:16:24Z","timestamp":1531944984000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Vancomycin-Resistant Enterococci and Its Associated Risk Factors among HIV-Positive and -Negative Clients Attending Dessie Referral Hospital, Northeast Ethiopia"],"prefix":"10.1155","volume":"2018","author":[{"given":"Seid","family":"Ali","sequence":"first","affiliation":[{"name":"Microbiology Laboratory Unit, Dessie Referral Hospital, Amhara Region, Dessie, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-5140","authenticated-orcid":true,"given":"Martha","family":"Alemayehu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulat","family":"Dagnew","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-3169","authenticated-orcid":true,"given":"Teklay","family":"Gebrecherkos","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, 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