{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:09:21Z","timestamp":1760472561537,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).<jats:italic>Methods.<\/jats:italic>24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15\u2009min after intravenous infusion of 250\u2009cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot\u2019s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs).<jats:italic>Results.<\/jats:italic>After infusion of HES blood flow velocities significantly increased in the CRA (PSV from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">7.53<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.33<\/mml:mn><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">8.32<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.51<\/mml:mn><\/mml:math>\u2009\u2009(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>); EDV from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn fontstyle=\"italic\">2.16<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.56<\/mml:mn><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn fontstyle=\"italic\">2.34<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.55<\/mml:mn><\/mml:math>\u2009\u2009(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>)) and in the PCAs (PSV from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn fontstyle=\"italic\">7.18<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1.62<\/mml:mn><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn fontstyle=\"italic\">7.56<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1.55<\/mml:mn><\/mml:math>\u2009\u2009(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>); EDV from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mn fontstyle=\"italic\">2.48<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.55<\/mml:mn><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mn fontstyle=\"italic\">2.66<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.6<\/mml:mn><\/mml:math>\u2009cm\/sec (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged.<jats:italic>Conclusions.<\/jats:italic>Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/drks.de\/drks_web\/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00012603\">DRKS00012603<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2018\/4756313","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T18:31:18Z","timestamp":1517941878000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-8356","authenticated-orcid":true,"given":"Marion","family":"Bienert","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Uniklinik RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8702-3963","authenticated-orcid":true,"given":"Niklas","family":"Plange","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Uniklinik RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Remky","sequence":"additional","affiliation":[{"name":"Augen-Beleg-Klinik, Krankenhaus Barmherzige Br\u00fcder, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay Oliver","family":"Arend","sequence":"additional","affiliation":[{"name":"Augenzentrum Annapark, Alsdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-6798","authenticated-orcid":true,"given":"David","family":"Kuerten","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Uniklinik RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00133273"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200306000-00012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199912000-00017"},{"issue":"3","key":"4","first-page":"171","volume":"48","year":"2000","journal-title":"Indian Journal of Ophthalmology"},{"issue":"5","key":"5","first-page":"420","volume":"14","year":"2001","journal-title":"Journal of Nephrology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/bf00159262"},{"issue":"5","key":"7","first-page":"1065","volume":"75","year":"1971","journal-title":"Transactions - 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