{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:30:59Z","timestamp":1771493459662,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status\u2019 association with bone mineral density evaluated by dual X-ray absorptiometry scan. <jats:italic>Methods<\/jats:italic>. We performed a cross section database study of adults at a tertiary CF Center. <jats:italic>Z<\/jats:italic> scores were applied for patients\u2009&lt;\u200950 years of age and <jats:italic>T<\/jats:italic> scores for patients\u2009&gt;\u200950 years of age. <jats:italic>Results<\/jats:italic>. One hundred twenty-five patients were included. Compared to nonosteoporotic patients, osteoporotic patients (15%) had significantly lower percent predicted forced expiratory volume in 1 second (ppFEV1), lower body mass index, higher frequency of CF-related diabetes and chronic lung infection, and higher high-sensitive C-reactive protein and glycated hemoglobin levels. Vitamin D was not associated with any outcome. In multivariate analyses, only ppFEV1 and female gender were independently associated with <jats:italic>Z<\/jats:italic> scores. <jats:italic>Conclusions<\/jats:italic>. Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor. Gender specific and dysglycemic impact on bone status should be investigated further.<\/jats:p>","DOI":"10.1155\/2018\/4803974","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T19:31:16Z","timestamp":1522092676000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-3575","authenticated-orcid":true,"given":"Inger Hee","family":"Mathiesen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen Cystic Fibrosis Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tacjana","family":"Pressler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen Cystic Fibrosis Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Danish Pediatric Pulmonary Service, Copenhagen Cystic Fibrosis Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oturai","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terese Lea","family":"Katzenstein","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen Cystic Fibrosis Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Skov","sequence":"additional","affiliation":[{"name":"Danish Pediatric Pulmonary Service, Copenhagen Cystic Fibrosis Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Frikke-Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette Friberg","family":"Hitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrine Division, Zealand University Hospital, Lykkebaekvej 1, 4600 Koege, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/926045"},{"key":"3","year":"2007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.10.819"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.05.009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.798"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3669"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60004-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2013.08.004"},{"key":"12","first-page":"1","volume":"843","year":"1994","journal-title":"World Health Organization Technical Report Series"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00050204"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-014-0572-z"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4179-9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3459"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0355-7"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1673-7"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.11.007"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1943OC"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9910118"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.82"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1629"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03216.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-387OC"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.03.002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3074"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.05.009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.104271"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.08.002"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3050"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.12.011"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.153"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00434-8"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220072"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-004-0803-1"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.04.039"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1024"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1982"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/4803974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/4803974.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/4803974.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T19:31:16Z","timestamp":1522092676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2018\/4803974\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":39,"alternative-id":["4803974","4803974"],"URL":"https:\/\/doi.org\/10.1155\/2018\/4803974","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}