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However, the role of LHRD in atherosclerosis treatment is still unclear. In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low\u2010density lipoprotein cholesterol (LDL\u2010C) levels in apolipoprotein E gene\u2010knockout (ApoE<jats:sup>-\/-<\/jats:sup>) mice fed with high fat and high cholesterol diet (western diet). Besides, LHRD treatment significantly reduced atherosclerotic lesion and plaques formation in both aortic roots and aortic trees. Furthermore, immunofluorescence staining in aortic roots demonstrated that LHRD treatment inhibited lectin\u2010like oxidized low\u2010density\u2010lipoprotein receptor\u20101 (LOX\u20101) expression in atherosclerotic plaques. These results indicated that LHRD ameliorated atherosclerosis via reducing serum levels of TC, TG, and LDL\u2010C as well as LOX\u20101 expression, subsequently attenuating atherosclerotic lesion and lipid deposition. In conclusion, LHRD could significantly attenuate experimental atherosclerosis and might be a novel potential drug for the prevention and treatment of atherosclerosis.<\/jats:p>","DOI":"10.1155\/2018\/4812639","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T23:38:33Z","timestamp":1539041913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effects of Chinese Traditional Medicine Longhu Rendan against Atherosclerosis via Negative Regulation of LOX\u20101"],"prefix":"10.1155","volume":"2018","author":[{"given":"Sishan","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-7263","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-6883","authenticated-orcid":false,"given":"Tian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13151"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.08.006"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.822515"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.11.009"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1882"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12689"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.010"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000183943.20277.26"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.164723"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13068"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/386073a0"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01418.x"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.09.009"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.09.019"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16740"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9004"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.152272"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02905-4"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1224-8"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6714282"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29085-3"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1314513"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411543"},{"key":"e_1_2_11_25_2","first-page":"80","article-title":"Role of macrophages in atherosclerosis. 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