{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:08:26Z","timestamp":1789412906010,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["OTKA-NN114458"],"award-info":[{"award-number":["OTKA-NN114458"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone. The aim of the present study was to investigate the anti\u2010inflammatory and analgesic effects of H\u00e9v\u00edz thermal water and mud in monosodium iodoacetate\u2010 (MIA\u2010) (25 mg\/ml, 20 <jats:italic>\u03bc<\/jats:italic>l i.a.) induced osteoarthritis and Complete Freund\u2019s adjuvant\u2010 (CFA\u2010) (1\u2009mg\/ml, 50\u201350\u2009<jats:italic>\u03bc<\/jats:italic>l s.c) induced rheumatoid arthritis murine models. The mechanonociceptive threshold of female NMRI mice (n=6\u2013 8 mice\/ group) was measured by aesthesiometry, and paw volume was monitored with plethysmometry, knee joint diameter with digital micrometer, and dynamic weight bearing on the hind limbs with a Bioseb instrument. Periarticular bone destruction was assessed by SkyScan 1176 in vivo micro\u2010CT. Inflammatory cytokines were detected by ELISA in plasma samples. Treatments (30 min, every working day) with tap water, sand, and a combined therapy of tap water and sand served as controls. H\u00e9v\u00edz medicinal water and combined treatment with water and mud significantly decreased the mechanical hyperalgesia and knee oedema in MIA\u2010induced osteoarthritis model. However, balneotherapy did not influence mechanical hyperalgesia, weight bearing, or oedema formation induced by CFA. Neither medicinal water nor mud treatment ameliorated deep structural damage of the bones or the joints in the animal models. On the basis of the present findings, we conclude that balneotherapy is an effective complementary treatment to reduce the pain sensation and swelling in degenerative joint diseases such as osteoarthritis. Our experimental data are in agreement with the previous human studies that also confirmed antinociceptive and anti\u2010inflammatory effects of thermal water and H\u00e9v\u00edz mud treatments.<\/jats:p>","DOI":"10.1155\/2018\/4816905","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:19:08Z","timestamp":1535415548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Investigation of Lake H\u00e9v\u00edz Mineral Water Balneotherapy and H\u00e9v\u00edz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models"],"prefix":"10.1155","volume":"2018","author":[{"given":"V.","family":"T\u00e9kus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-4391","authenticated-orcid":false,"given":"\u00c9.","family":"Borb\u00e9ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perkecz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Kem\u00e9ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kvarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-632X","authenticated-orcid":false,"given":"E.","family":"Pint\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-015-0980-3"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-013-0667-6"},{"key":"e_1_2_9_3_2","first-page":"373","article-title":"Evaluation of the effect of Lake Heviz thermal mineral water in patients with osteoarthritis of the knee: a randomized, controlled, single-blind, follow-up study","volume":"50","author":"Kulisch A.","year":"2014","journal-title":"European Journal of Physical and Rehabilitation Medicine"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.60.2013.2.11"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1556\/030.63.2016.1.9"},{"key":"e_1_2_9_6_2","first-page":"177","article-title":"Evaluation of the Effect of Heviz Mud in Patients with Hand Osteoarthritis: A Randomized, Controlled, Single-Blind Follow-Up Study","volume":"19","author":"Gyarmati N.","year":"2017","journal-title":"Israel Medical Association Journal"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.1916"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S8797"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-017-1441-y"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-017-1446-6"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.65"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061687"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1114-2"},{"key":"e_1_2_9_14_2","first-page":"30","article-title":"Kett\u0151s vak k\u00eds\u00e9rlet a kiskunhalasi term\u00e1lv\u00edz ter\u00e1pi\u00e1s hat\u00e1s\u00e1nak m\u00e9r\u00e9s\u00e9re rheumatoid arthritises betegeken","volume":"22","author":"Bathory G.","year":"1981","journal-title":"Magy Reum"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/146642408910900104"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-561-9_18"},{"key":"e_1_2_9_17_2","first-page":"1001","article-title":"Development of osteoarthritic lesions in mice by \u201cmetabolic\u201d and \u201cmechanical\u201d alterations in the knee joints","volume":"135","author":"van der P. 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