{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:10:32Z","timestamp":1790680232848,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,10,8]]},"abstract":"<jats:p>\n                    This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induces hypotension and vasodilatation in mesenteric arteries, with or without vascular endothelium. JSJ-mediated vasodilation response against contractions induced with KCl (60\u2009mM) depolarizing solution was significantly lower than the responses induced by JSJ when evaluated against phenylephrine-induced contractions. To investigate the involvement of potassium channels we used Tyrode\u2019s solution with KCl (20 mM) or tetraethylammonium (1.0, 3.0, or 5.0 mM). In these conditions JSJ-induced effects were significantly attenuated. To investigate the potassium channel subtypes involved in the response, we used 4-aminopyridine, glibenclamide, BaCl\n                    <jats:sub>2<\/jats:sub>\n                    , and iberiotoxin. In the presence (simultaneous) of different potassium channel blockers we observed a significant attenuation of JSJ-induced effect. Inhibition was also observed when using BaCl\n                    <jats:sub>2<\/jats:sub>\n                    , glibenclamide, or 4-aminopyridine, separately. However, incubation with iberiotoxin did not promote changes in either maximum effect, or potency. We also evidenced a discrete participation of\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mtext>C<\/mml:mtext>\n                      <mml:msub>\n                        <mml:mrow>\n                          <mml:mtext>a<\/mml:mtext>\n                        <\/mml:mrow>\n                        <mml:mrow>\n                          <mml:mtext>V<\/mml:mtext>\n                        <\/mml:mrow>\n                      <\/mml:msub>\n                    <\/mml:math>\n                    channels in the JSJ-induced vasorelaxant effect. In addition, patch-clamp studies demonstrated that JSJ could activate potassium channels. In conclusion, JSJ promotes hypotension and vasorelaxation in rats, involving, at least, the activation of potassium channels.\n                  <\/jats:p>","DOI":"10.1155\/2018\/4827461","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T19:39:20Z","timestamp":1539027560000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried\n                    <i>Syzygium jambolanum<\/i>\n                    (Lam.) DC Fruit Juice"],"prefix":"10.1155","volume":"2018","author":[{"given":"K\u00edvia S.","family":"Assis","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islania G. A.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima de L. A. A.","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla M. P.","family":"Maciel","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia T.","family":"Machado Calzerra","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tays A. F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria L.","family":"Assis","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos\/Centro de Ci\u00eancias da Sa\u00fade (CCS)\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliny P.","family":"de Vasconcelos","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia, Centro de Biotecnologia\/Universidade Federal da Para\u00edba (UFPB), Jo\u00e3o Pessoa 58059-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A. 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