{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:51:34Z","timestamp":1790808694899,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":107,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91649114"],"award-info":[{"award-number":["91649114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471299"],"award-info":[{"award-number":["81471299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative disease and is known to involve circadian dysfunction and oxidative stress. Although antioxidative defense is regulated by the molecular circadian clock, few studies have examined their function in PD and their regulation by silent information regulator 1 (SIRT1). We hypothesize that reduced antioxidative activity in models of PD results from dysfunction of the molecular circadian clock via the SIRT1 pathway. We treated rats and SH\u2010SY5Y cells with 6\u2010hydroxydopamine (6\u2010OHDA) and measured the expression of core circadian clock and associated nuclear receptor genes using real\u2010time quantitative PCR as well as levels of SIRT1, brain and muscle Arnt\u2010like protein 1 (BMAL1), and acetylated BMAL1 using Western blotting. We found that 6\u2010OHDA treatment altered the expression patterns of clock and antioxidative molecules <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. We also detected an increased ratio of acetylated BMAL1:BMAL1 and a decreased level of SIRT1. Furthermore, resveratrol, an activator of SIRT1, decreased the acetylation of BMAL1 and inhibited its binding with <jats:italic>CRY1<\/jats:italic>, thereby reversing the impaired antioxidative activity induced by 6\u2010OHDA. These results suggest that a dysfunctional circadian clock contributes to an abnormal antioxidative response in PD via a SIRT1\u2010dependent BMAL1 pathway.<\/jats:p>","DOI":"10.1155\/2018\/4854732","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T23:35:37Z","timestamp":1524094537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1\u2010BMAL1 Pathway in 6\u2010OHDA\u2010Induced Models of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-2929","authenticated-orcid":false,"given":"Yali","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-2445","authenticated-orcid":false,"given":"Dongjun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8326-7779","authenticated-orcid":false,"given":"Li-Fang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-0219","authenticated-orcid":false,"given":"Chun-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17909-4"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0089-7"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02848.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.08.003"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/417329a"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153128"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00144-1"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(97)00043-0"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1432206"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.07.011"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101353"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317100-00004"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.04.020"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.07.046"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90390-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.13-108"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.09.008"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.05.059"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.013"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.050"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.002"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-232629"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7589813"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26865"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-012-8214-x"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2128-10.2010"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510691103"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5558"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb925"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu4101399"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209148109"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10864"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06394"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-2027"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/4854732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/4854732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/4854732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:01:49Z","timestamp":1723028509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/4854732"}},"subtitle":[],"editor":[{"given":"Consuelo","family":"Borr\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/4854732"],"URL":"https:\/\/doi.org\/10.1155\/2018\/4854732","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4854732"}}