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O\u2010linked <jats:italic>\u03b2<\/jats:italic>\u2010N\u2010acetylglucosamine (O\u2010GlcNAc) glycosylation of intracellular proteins denotes a type of posttranslational modification that influences multiple cytoplasmic and nuclear protein functions. Growing evidence indicates that stress can induce an acute increase in O\u2010GlcNAc levels, which can be cytoprotective. The current study aimed to determine whether RIPC can provide renoprotection against contrast\u2010induced acute kidney injury (CI\u2010AKI) by augmenting O\u2010GlcNAc signaling. We established a stable model of CI\u2010AKI using 5\/6 nephrectomized rats exposed to dehydration followed by iohexol injection via the tail vein. We found that RIPC increased UDP\u2010GlcNAc levels through the hexosamine biosynthetic pathway as well as global renal O\u2010GlcNAcylation. RIPC\u2010induced elevation of O\u2010GlcNAc signaling ameliorated CI\u2010AKI based on the presence of less tubular damage and apoptosis and the amount of reactive oxygen species. In addition, the use of alloxan, an O\u2010GlcNAc transferase inhibitor, and azaserine, a glutamine fructose\u20106\u2010phosphate amidotransferase inhibitor, neutralized the protective effect of RIPC against oxidative stress and tubular apoptosis. In conclusion, RIPC attenuates local oxidative stress and tubular apoptosis induced by contrast exposure by enhancing O\u2010GlcNAc glycosylation levels; this can be a potentially useful approach for lowering the risk of CI\u2010AKI.<\/jats:p>","DOI":"10.1155\/2018\/4895913","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T23:32:54Z","timestamp":1534203174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Remote Ischemic Preconditioning Ameliorates Acute Kidney Injury due to Contrast Exposure in Rats through Augmented O\u2010GlcNAcylation"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0262-0935","authenticated-orcid":false,"given":"Jiachang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-0257","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-5495","authenticated-orcid":false,"given":"Xiaoqiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12193"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05200709"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413534"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413579"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1272-y"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001381"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0405-4"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.12.032"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.014"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs337"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/427560"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.10.509"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.155"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31822fcede"},{"key":"e_1_2_11_15_2","first-page":"3273","article-title":"Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas","volume":"47","author":"Lhoste E. 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