{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:53:07Z","timestamp":1786625587505,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T00:00:00Z","timestamp":1546128000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471987"],"award-info":[{"award-number":["81471987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017ZX10302301-001"],"award-info":[{"award-number":["2017ZX10302301-001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of the Thirteenth Five-Year Plan of China","award":["81471987"],"award-info":[{"award-number":["81471987"]}]},{"name":"Major Project of the Thirteenth Five-Year Plan of China","award":["2017ZX10302301-001"],"award-info":[{"award-number":["2017ZX10302301-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,12,30]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem. The aim of this study was to determine the antibiotic susceptibility profiles of clinical isolates of<jats:italic> Mycobacterium abscessus and Mycobacterium fortuitum. Methods<\/jats:italic>. We performed susceptibility tests on 37 clinical NTM isolates to 30 antibiotics with the microdilution method recommended by the Clinical and Laboratory Standards Institute.<jats:italic> Results<\/jats:italic>. Both<jats:italic> M. abscessus<\/jats:italic> and<jats:italic> M. fortuitum<\/jats:italic> were highly resistant to antitubercular drugs such as isoniazid, rifampin, ethambutol, clofazimine, ethionamide, and rifabutin.<jats:italic> M. abscessus<\/jats:italic> showed the lowest resistant rates to cefoxitin (10%), azithromycin (10%), amikacin (10%), and clarithromycin (20%) and very high resistant to sulfamethoxazole, vancomycin, oxacillin, clindamycin, and all fluoroquinolones.<jats:italic> M. fortuitum<\/jats:italic> showed low resistance to tigecycline (0%), tetracycline (0%), cefmetazole (12%), imipenem (12%), linezolid (18%), and the aminoglycosides amikacin (0%), tobramycin (0%), neomycin (0%), and gentamycin (24%).<jats:italic> Conclusion. <\/jats:italic>Amikacin, cefoxitin, and azithromycin have the highest<jats:italic> in vitro<\/jats:italic> activity against<jats:italic> M. abscessus<\/jats:italic>. Isolates of<jats:italic> M. fortuitum<\/jats:italic> need to be individually evaluated for drug susceptibility before choosing an effective antimicrobial regimen for treatment of infections.<\/jats:p>","DOI":"10.1155\/2018\/4902941","type":"journal-article","created":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T18:31:17Z","timestamp":1546194677000},"page":"1-10","source":"Crossref","is-referenced-by-count":64,"title":["<i>In Vitro<\/i> Susceptibility of<i> Mycobacterium abscessus<\/i> and<i> Mycobacterium fortuitum<\/i> Isolates to 30 Antibiotics"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yaojie","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-3766","authenticated-orcid":true,"given":"Jiazhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2017.1386563"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2016OC"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.12.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.02.014"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.10.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.716-746.2002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0597-2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1238304"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12333"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.03.010"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy036"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr154"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140166"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"16","volume":"2017","year":"2017","journal-title":"BMJ Case Reports"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2017.05.135"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh523"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204260"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0843"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00652-10"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx212"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw723"},{"key":"40","first-page":"85","volume":"2","year":"2016","journal-title":"Biomed Environ SCI"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002338"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.12.007"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/419392"},{"key":"42","first-page":"236","volume":"3","year":"2015","journal-title":"Clinical Microbiology &amp; 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