{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:51:23Z","timestamp":1787496683690,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007941","name":"Addis Ababa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,7,4]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Lipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To assess insulin-induced lipodystrophy and glycemic control.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.\n                    <jats:italic>Result<\/jats:italic>\n                    . Out of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Findings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.\n                  <\/jats:p>","DOI":"10.1155\/2018\/4910962","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T19:33:43Z","timestamp":1530732823000},"page":"1-7","source":"Crossref","is-referenced-by-count":33,"title":["Effect of Insulin-Induced Lipodystrophy on Glycemic Control among Children and Adolescents with Diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia"],"prefix":"10.1155","volume":"2018","author":[{"given":"Afewerki Gebremeskel","family":"Tsadik","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-2258","authenticated-orcid":true,"given":"Tesfay Mehari","family":"Atey","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-7042","authenticated-orcid":true,"given":"Teshome","family":"Nedi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bereket","family":"Fantahun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, St. Paul\u2019s Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2736-6064","authenticated-orcid":true,"given":"Mamo","family":"Feyissa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, 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