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Several natural products, including sulfur\u2010containing compounds, have been investigated for their antifibrotic effects; however, the molecular mechanisms underpinning their action are partially still obscure. In this study, we have investigated for the first time the effect of ovothiol A, <jats:italic>\u03c0<\/jats:italic>\u2010methyl\u20105\u2010thiohistidine, isolated from sea urchin eggs on an <jats:italic>in vivo<\/jats:italic> murine model of liver fibrosis. Mice were intraperitoneally injected with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) to induce liver fibrosis and treated with ovothiol A at the dose of 50\u2009mg\/kg 3 times a week for 2 months. Treatment with ovothiol A caused a significant reduction of collagen fibers as observed by histopathological changes and serum parameters compared to mice treated with control solution. This antifibrotic effect was associated to the decrease of fibrogenic markers involved in liver fibrosis progression, such as the transforming growth factor (TGF\u2010<jats:italic>\u03b2<\/jats:italic>), the <jats:italic>\u03b1<\/jats:italic>\u2010smooth muscle actin (\u03b1\u2010SMA), and the tissue metalloproteinases inhibitor (TIMP\u20101). Finally, we provided evidence that the attenuation of liver fibrosis by ovothiol A treatment can be regulated by the expression and activity of the membrane\u2010bound <jats:italic>\u03b3<\/jats:italic>\u2010glutamyl\u2010transpeptidase (GGT), which is a key player in maintaining intracellular redox homoeostasis. Overall, these findings indicate that ovothiol A has significant antifibrotic properties and can be considered as a new marine drug or dietary supplement in potential therapeutic strategies for the treatment of liver fibrosis.<\/jats:p>","DOI":"10.1155\/2018\/5045734","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T23:36:54Z","timestamp":1545089814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antifibrotic Effect of Marine Ovothiol in an <i>In Vivo<\/i> Model of Liver 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