{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:25:00Z","timestamp":1776234300805,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Sporadic inclusion body myositis (sIBM) is considered the most common acquired myopathy aged over 50 years. The disease is characterized by a particular process of muscle degeneration characterized by abnormal deposit of protein aggregates in association with inflammation. The aim of this study was to present clinical and muscle histopathological findings, including immunostaining for LC3B, p62, <jats:italic>\u03b1<\/jats:italic>-synuclein, and TDP-43, in 18 patients with sIBM. The disease predominated in males (61%) and European descendants, with onset of clinical manifestations around 59 years old. The most common symptoms were muscle weakness, falls, dysphagia, and weight loss. Hypertension was the main comorbidity. Most of the cases presented with paresis predominantly proximal in lower limbs and distal in upper limbs. Immunosuppressive treatment showed to be not effective. Muscle histological findings included dystrophic changes, endomysial inflammation, increased lysosomal activity, and presence of rimmed vacuoles and of beta-amyloid accumulation, in addition to high frequency of mitochondrial changes. There was increased expression of LC3B, p62, <jats:italic>\u03b1<\/jats:italic>-synuclein, and TDP-43 in muscle biopsies. The sIBM has characteristic clinical and histological findings, and the use of degeneration and autophagic markers can be useful for the diagnosis.<\/jats:p>","DOI":"10.1155\/2018\/5069042","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T18:30:48Z","timestamp":1517250648000},"page":"1-15","source":"Crossref","is-referenced-by-count":26,"title":["Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Leonardo Valente de","family":"Camargo","sequence":"first","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Souza de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Katsuyuki","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Disciplina de Reumatologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Acary Souza Bulle de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Setor de Doen\u00e7as Neuromusculares, Disciplina de Neurologia, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-6760","authenticated-orcid":true,"given":"Edmar","family":"Zanoteli","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<970::AID-MUS20>3.0.CO;2-I"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00021-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.3.727"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0884-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0261"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192260.33106.bb"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70171-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.173823"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.2.325"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.03.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2010.11.024"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.042"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12384"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.03.023"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06461.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380504"},{"key":"17"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.03.014"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.11.003"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.08.007"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305690"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004552"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000642"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"25","first-page":"61","volume":"14","year":"1965","journal-title":"Maryland State Medical Journal"},{"key":"26","first-page":"16","volume-title":"Histological and histochemical stains and reactions","year":"2013"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530240033013"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2015.06.004"},{"issue":"3","key":"29","first-page":"179","volume":"38","year":"2013","journal-title":"Acta Reumatol\u00f3gica Portuguesa"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12480"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23840"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23822"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24199"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.07.002"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.8.1253"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2001.210509.x"},{"issue":"11","key":"37","first-page":"370","volume":"92","year":"2001","journal-title":"Fukuoka Igaku Zasshi"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002291"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000300033"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.1887"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100036684"},{"issue":"4","key":"42","first-page":"334","volume":"21","year":"2001","journal-title":"Annales De Pathologie"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken252"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.190751"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.12.005"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.5002"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1159\/000441490"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5069042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5069042.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5069042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T18:30:48Z","timestamp":1517250648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/5069042\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":47,"alternative-id":["5069042","5069042"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5069042","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}