{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:40:05Z","timestamp":1781163605471,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI16C0047"],"award-info":[{"award-number":["HI16C0047"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The aim of this study was to explore if measurement of pretransplant circulating CD161-expressing cells, in addition to clinical risk factors, could predict mucositis and infections in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT). To determine if CD161-expressing cells are likely to predict early complications, namely, mucositis (\u2265grade 3), infections, and cytomegalovirus (CMV) reactivation, we prospectively examined CD161-expressing cells (CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>CD161<jats:sup>+<\/jats:sup>and CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup>CD161<jats:sup>+<\/jats:sup>) in peripheral blood samples from 108 patients with MM undergoing ASCT. After adjusting for factors identified by univariate analysis that predicted mucositis (\u2265grade 3), infection before engraftment, and CMV reactivation, multivariate analyses revealed that the low proportion of CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>CD161<jats:sup>+<\/jats:sup>cells in peripheral blood was an independent predictor of mucositis (\u2265grade 3) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.020<\/mml:mn><\/mml:math>), infections before engraftment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.014<\/mml:mn><\/mml:math>), and CMV reactivation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.010<\/mml:mn><\/mml:math>). In addition, we found that female sex and decreased glomerular filtration rate were independent factors for predicting mucositis. Female sex and severe pulmonary comorbidity were independent factors for predicting infection before engraftment. We found that the proportion of circulating CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>CD161<jats:sup>+<\/jats:sup>cells is useful for predicting the occurrence of early complications, including mucositis and infections, after ASCT in patients with MM.<\/jats:p>","DOI":"10.1155\/2018\/5097325","type":"journal-article","created":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T23:30:41Z","timestamp":1514849441000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Circulating CD3<sup>+<\/sup>CD4<sup>+<\/sup>CD161<sup>+<\/sup>Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-2050","authenticated-orcid":true,"given":"Sung-Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Bin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Woo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Sik","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-126X","authenticated-orcid":true,"given":"Ki-Seong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-3366","authenticated-orcid":true,"given":"Hee-Je","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Goo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-4166","authenticated-orcid":true,"given":"Jong Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Sung","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-0392","authenticated-orcid":true,"given":"Chang-Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Hematology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022340"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402888"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.255"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24402"},{"issue":"5","key":"5","first-page":"231","volume":"5","year":"2007","journal-title":"The Journal of Supportive Oncology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702822"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.01.004"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000041"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12643"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.655421"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1911-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-290080"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.3.397"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2004"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350204"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.127"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1159\/000318880"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)61424-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-355081"},{"issue":"8","key":"20","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1182\/blood-2012-02-408922","volume":"120","year":"2012","journal-title":"Blood"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114138"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.09.010"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13532"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02021.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.06.003"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21746"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.10.2992"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-007-0007-y"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0977"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.021"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q"},{"issue":"6","key":"32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1634\/theoncologist.3-6-446","volume":"3","year":"1998","journal-title":"The Oncologist"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.10.1562"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2446"},{"issue":"3","key":"35","first-page":"325","volume":"15","year":"1988","journal-title":"Oncol Nurs Forum"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.008"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00346"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5097325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5097325.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/5097325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T03:13:59Z","timestamp":1603595639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/5097325\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":38,"alternative-id":["5097325","5097325"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5097325","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}