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Oxygen\/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen\/ozone could attenuate chronic radiculitis and mechanical allodynia after noncompressive lumbar disc herniation and at elucidating the underlying mechanisms. <jats:italic>Methods<\/jats:italic>. First, we transplanted autologous nucleus pulposus into dorsal root ganglions to establish chronic radiculitis in rats. Then, filtered oxygen or oxygen\/ozone (10, 20, or 30\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) was intrathecally injected on day 1 after surgery. The ipsilateral paw withdrawal thresholds (PWTs) to mechanical stimuli were tested daily with von Frey filaments. The expression of the tumor necrosis factor- (TNF-) <jats:italic>\u03b1<\/jats:italic>, interleukin- (IL-) 1<jats:italic>\u03b2<\/jats:italic>, IL-6, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), phosphodiesterase 2A (PDE2A), and nuclear factor- (NF-) <jats:italic>\u03ba<\/jats:italic>B\/p65 in spinal dorsal horns was measured by enzyme-linked immunosorbent assay, polymerase chain reaction, and western blot on day 7 after surgery. <jats:italic>Results<\/jats:italic>. Chronic radiculitis was established in rats. Intrathecal administration of 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, 20\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, or 30\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL oxygen\/ozone significantly attenuated the decreased mechanical PWTs, downregulated the overexpression of spinal TNF-<jats:italic>\u03b1<\/jats:italic>, IL-1<jats:italic>\u03b2<\/jats:italic>, and IL-6, and increased the expression of cGMP and cAMP in chronic radiculitis rats. In addition, the effects of treatment with 20\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL oxygen\/ozone were greater than the effects of the 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL or 30\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL doses. Moreover, intrathecal administration of 20\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL oxygen\/ozone reversed the increased levels of spinal PDE2A and NF-<jats:italic>\u03ba<\/jats:italic>B\/p65 mRNA and protein expressions in rats with chronic radiculitis. <jats:italic>Conclusion<\/jats:italic>. Intrathecal administration of low-concentration oxygen\/ozone alleviated mechanical allodynia and attenuated radiculitis, likely by a PDE2A-cGMP\/cAMP-NF-<jats:italic>\u03ba<\/jats:italic>B\/p65 signaling pathway in chronic radiculitis rats.<\/jats:p>","DOI":"10.1155\/2018\/5192814","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T18:31:49Z","timestamp":1544725909000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["Low-Concentration Oxygen\/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP\/cGMP-NF-<i>\u03ba<\/i>B\/p65 Signaling in Chronic Radiculitis Rats"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-8178","authenticated-orcid":true,"given":"Junnan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, 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