{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:03:06Z","timestamp":1778713386178,"version":"3.51.4"},"reference-count":129,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cell Biology"],"published-print":{"date-parts":[[2018,9,19]]},"abstract":"<jats:p>Seipin is a nonenzymatic protein encoded by the<jats:italic> BSCL2<\/jats:italic> gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway.<\/jats:p>","DOI":"10.1155\/2018\/5207608","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T20:04:19Z","timestamp":1537387459000},"page":"1-21","source":"Crossref","is-referenced-by-count":15,"title":["Exploring Seipin: From Biochemistry to Bioinformatics Predictions"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-830X","authenticated-orcid":true,"given":"Aquiles Sales","family":"Craveiro Sarmento","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Gen\u00f4mica, Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-0795","authenticated-orcid":true,"given":"L\u00e1zaro Batista","family":"de Azevedo Medeiros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Gen\u00f4mica, Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-3162","authenticated-orcid":true,"given":"Lucymara Fassarella","family":"Agnez-Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Gen\u00f4mica, Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-7018","authenticated-orcid":true,"given":"Josivan Gomes","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Cl\u00ednica, Hospital Universit\u00e1rio Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-5521","authenticated-orcid":true,"given":"Julliane Tamara Ara\u00fajo","family":"de Melo Campos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Gen\u00f4mica, Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-016-0140-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-14-2-193"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.38.201.447"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/ng585"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/ng1313"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.05.004"},{"issue":"9","key":"7","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1151-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1210-1248"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0236"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0184"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1071"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh131"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030485"},{"key":"16","volume":"15, article 71","year":"2014","journal-title":"BMC Medical Genetics"},{"issue":"5","key":"17","first-page":"440","volume":"43","year":"2006","journal-title":"Indian Pediatrics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-78"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0899-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.10.722"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030855"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031211"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(10)70094-2"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12623"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2011_86"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1005"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03532.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3556"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02863.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0393"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2008.10.006"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr245"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.03.040"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.07.009"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(03)00078-X"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.2741\/A656"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200711136"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704154104"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16582"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-015-0611-3"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003731"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06465-11"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1067"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1344"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.164"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1021\/bi1013003"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3029-3"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-411619-1.00009-4"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/nature17041"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/589589"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.10.015"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-385114-7.00004-0"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4074"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.32"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3579"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4567-7_8"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.76"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121870"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2014.09.015"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008417"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.123"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2017.07.003"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2809-5"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.015"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057874"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.610407.x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030835"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M017566"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001364"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-016-4210-5"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0729"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082526"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0327"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv156"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01120-15"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/srep35487"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695170"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324025111"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu126"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.021550"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3280-15.2016"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0598-3"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0471-7"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox169"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.04.116"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20090785"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.01.011"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr205"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-015-0054-x"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1292"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.02.147"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.117"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.01.019"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00237.2011"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1966.tb00007.x"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20792"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21070"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr304"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.64"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds523"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199052"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20410"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1021-6"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh232"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.22045\/ibj.2016.07"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.08.006"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101525"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-017-0052-8"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1138"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt444"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.028"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201610013"},{"issue":"23","key":"110","first-page":"5111","volume":"25","year":"2016","journal-title":"Human Molecular Genetics"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.12.013"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2012.11.002"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1038\/ng880"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.296681"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.072488"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.07.022"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609140103"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M006304"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1038\/srep07633"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M007054"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.010"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.037"},{"key":"123","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1152\/ajpendo.00440.2004","volume":"288","year":"2005","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.050567"}],"container-title":["International Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2018\/5207608.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2018\/5207608.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2018\/5207608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T19:41:06Z","timestamp":1538682066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijcb\/2018\/5207608\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":129,"alternative-id":["5207608","5207608"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5207608","relation":{},"ISSN":["1687-8876","1687-8884"],"issn-type":[{"value":"1687-8876","type":"print"},{"value":"1687-8884","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]}}}