{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:31:25Z","timestamp":1766269885375,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IBRAMED"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2018,11,29]]},"abstract":"<jats:p>Cryolipolysis is the noninvasive treatment of localized fat through cold-induced panniculitis. The purpose of the present study was to evaluate the safety and efficacy of contrast cryolipolysis for subcutaneous-fat reduction. Contrast cryolipolysis mixes the principles of conventional cryolipolysis and periods of heating in accordance with the contrast lipocryolysis process. Twenty-one subjects aged 34 \u00b1 9 years were treated with contrast cryolipolysis in the regions of abdomen and flanks through the Polarys\u00ae device. Anthropometry, standardized photographs, measurements with a skinfold caliper, and diagnostic ultrasounds were performed at the baseline and during follow-ups at 30, 60, and 90 days after the treatment. The safety assessments included laboratory testing and monitoring of the adverse events. The level of significance for all tests was set at<jats:italic> P <\/jats:italic>&lt; 0.05. No significant differences in weight and body mass index were found. The waist measurements at the baseline and 30-day follow-up had significant differences, as did the measurements at the 30-day and 60-day follow-ups. The skinfold and ultrasound measurements were significantly reduced in the treated areas in all the time points compared to the baseline. The laboratory results showed no significant changes from baseline. Temporary adverse effects were resolved spontaneously. This study confirmed that contrast cryolipolysis is safe and effective in reducing the fat layer and improving body contouring.<\/jats:p>","DOI":"10.1155\/2018\/5276528","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:30:45Z","timestamp":1543516245000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Effectiveness and Safety of Contrast Cryolipolysis for Subcutaneous-Fat Reduction"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mar\u00edlia Bueno","family":"Savacini","sequence":"first","affiliation":[{"name":"Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Tazinaffo","family":"Bueno","sequence":"additional","affiliation":[{"name":"Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Souza","family":"Molina","sequence":"additional","affiliation":[{"name":"Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Caroline Almeida","family":"Lopes","sequence":"additional","affiliation":[{"name":"Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Nogueira","family":"Silva","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"},{"name":"Research, Development & Innovation Department IBRAMED, Ibramed Research Group (IRG), Amparo, Brazil"},{"name":"Human Development and Technologies. Universidade Estadual Paulista (UNESP), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Gomes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"},{"name":"Research, Development & Innovation Department IBRAMED, Ibramed Research Group (IRG), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephani","family":"Almeida","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"},{"name":"Research, Development & Innovation Department IBRAMED, Ibramed Research Group (IRG), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Michelini","family":"Guidi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"},{"name":"Research, Development & Innovation Department IBRAMED, Ibramed Research Group (IRG), Amparo, Brazil"},{"name":"Electrical Engineering Department, Faculty of Medical Sciences, University of Campinas (Unicamp), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-6019","authenticated-orcid":true,"given":"Estela","family":"Sant\u2019Ana","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Ibramed Center for Education and Advanced Training (CEFAI), Amparo, Brazil"},{"name":"Research, Development & Innovation Department IBRAMED, Ibramed Research Group (IRG), Amparo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Eloin","family":"Liebano","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Federal University of S\u00e3o Carlos, S\u00e3o Carlos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2015.1066534"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.12.060"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.11.005"},{"volume":"4","journal-title":"F1000Research","year":"2015","key":"5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20925"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-008-9273-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X12469627"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/14764170510037743"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20864"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4161\/adip.28547"},{"issue":"2","key":"12","first-page":"154","volume":"35","year":"2014","journal-title":"Cryoletters"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4172\/2153-0637.1000122"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12238"},{"volume":"22","journal-title":"Eplasty","year":"2014","key":"15"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1781-y"},{"key":"17","first-page":"201","volume":"7","year":"2014","journal-title":"Clinical, Cosmetic and Investigational Dermatology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.233"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sju024"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22550"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12386"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw250"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12238"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21145"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22209"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S102503"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6052194"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv039"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20719"},{"issue":"1","key":"30","first-page":"31","volume":"32","year":"2013","journal-title":"Seminars in Cutaneous Medicine and Surgery"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01259.x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22440"},{"issue":"1","key":"33","first-page":"100","volume":"34","year":"2013","journal-title":"Cryoletters"},{"issue":"3","key":"34","first-page":"177","volume":"33","year":"2012","journal-title":"Cryoletters"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X13520320"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/PSN.0b013e3182066c87"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20850"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22302"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000001236"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X13494757"}],"container-title":["Dermatology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2018\/5276528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2018\/5276528.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2018\/5276528.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:30:47Z","timestamp":1543516247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/drp\/2018\/5276528\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":39,"alternative-id":["5276528","5276528"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5276528","relation":{},"ISSN":["1687-6105","1687-6113"],"issn-type":[{"type":"print","value":"1687-6105"},{"type":"electronic","value":"1687-6113"}],"subject":[],"published":{"date-parts":[[2018,11,29]]}}}