{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:11:38Z","timestamp":1787083898291,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2013\/11\/D\/NZ2\/00033"],"award-info":[{"award-number":["2013\/11\/D\/NZ2\/00033"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["OTKA PD 116845"],"award-info":[{"award-number":["OTKA PD 116845"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["OTKA K112336"],"award-info":[{"award-number":["OTKA K112336"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00048-STAYALIVE"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00048-STAYALIVE"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00020 TUMORDNS"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00020 TUMORDNS"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Wound healing is a complex multiphase process which can be hampered by many factors including impaired local circulation, hypoxia, infection, malnutrition, immunosuppression, and metabolic dysregulation in diabetes. Redox dysregulation is a common feature of many skin diseases demonstrated by virtually all cell types in the skin with overproduction of reactive oxygen and nitrogen species. The objective of this study was to characterize the redox environment in wound fluids and sera from patients suffering from chronic leg ulcers (\n                    <jats:italic>n<\/jats:italic>\n                    = 19) and acute wounds (bulla fluids from second degree burns;\n                    <jats:italic>n<\/jats:italic>\n                    = 11) with serum data also compared to those from healthy volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    = 7). Significantly higher concentrations of TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , interleukine\u20108, vascular endothelial growth factor, and lactate dehydrogenase (measure of cell damage) were found in fluids from chronic wounds compared to acute ones. The extent of protein carbonylation (measure of protein oxidation), lipid peroxidation, and tyrosine nitration (indicator of peroxynitrite production) was similar in acute and chronic wound fluids, while radical scavenging activity and glutathione (GSH) levels were elevated in chronic wound fluids compared to acute wounds. Sera were also assessed for the same set of parameters with no significant differences detected. Nitrotyrosine (the footprint of the potent oxidant peroxynitrite) and poly(ADP\u2010ribose) (the product of the DNA damage sensor enzyme PARP\u20101) could be detected in wound biopsies. Our data identify multiple signs of redox stress in chronic wounds with notable differences. In chronic wounds, elevations in antioxidant levels\/activities may indicate compensatory mechanisms against inflammation. The presence of nitrotyrosine and poly(ADP\u2010ribose) in tissues from venous leg ulcers indicate peroxynitrite production and PARP activation in chronic wounds.\n                  <\/jats:p>","DOI":"10.1155\/2018\/5286785","type":"journal-article","created":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T18:36:31Z","timestamp":1542566191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds"],"prefix":"10.1155","volume":"2018","author":[{"given":"Edina","family":"Bodn\u00e1r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Bakondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Heged\u0171s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Robaszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Regdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-6718","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Vir\u00e1g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-9281","authenticated-orcid":false,"given":"\u00c9va","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,18]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"World Health Organization Injuries 2017 http:\/\/www.who.int\/topics\/injuries\/about\/en\/."},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12220"},{"key":"e_1_2_9_3_2","unstructured":"Medscape Wound care 2017 http:\/\/emedicine.medscape.com\/article\/194018-overview#a5."},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13544"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.4172\/2576-1471.1000e101"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12217"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110301.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/83241"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13735"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00130"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12216"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.03.407"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01388.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00329-0"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/178513"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09637480600798132"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.01.006"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.192-198.2002"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100006X116600"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1299"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.09.032"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211999200"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203391200"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1401452"},{"key":"e_1_2_9_25_2","first-page":"319","article-title":"Auto-oxidation test for the determination of lipid peroxidation capacity of liver tissue homogenates of young and old mice","volume":"24","author":"Vir\u00e1g L.","year":"1991","journal-title":"Zeitschrift f\u00fcr Gerontologie"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.t01-1-10605.x"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475x.2010.00586.x"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/5286785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/5286785.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/5286785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:04:34Z","timestamp":1723014274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/5286785"}},"subtitle":[],"editor":[{"given":"Kota V.","family":"Ramana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/5286785"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5286785","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5286785"}}