{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:43:16Z","timestamp":1790829796803,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian agencies Rio de Janeiro State Research Foundation"},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordination for Improvement of Higher Education Personnel"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2018,7,5]]},"abstract":"\n Piper<\/jats:italic>\n is the largest genus of the Piperaceae family. The species of this genus have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica, and Mexico. In Brazil,\n Piper<\/jats:italic>\n species are distributed throughout the national territory, making this genus a good candidate for biological activity screening. During our studies with\n Piper<\/jats:italic>\n essential oils, we evaluated its activity against\n Rhizopus oryzae<\/jats:italic>\n , the main agent of mucormycosis. The main compounds of seven\n Piper<\/jats:italic>\n essential oils analyzed were\n Piper callosum<\/jats:italic>\n \u2014safrole (53.8%),\n P. aduncum<\/jats:italic>\n \u2014dillapiole (76.0%),\n P. hispidinervum<\/jats:italic>\n \u2014safrole (91.4%),\n P. marginatum<\/jats:italic>\n \u2014propiopiperone (13.2%),\n P. hispidum<\/jats:italic>\n \u2014\u03b3-terpinene (30.9%),\n P. tuberculatum<\/jats:italic>\n \u2014(\n E<\/jats:italic>\n )-caryophyllene (30.1%), and\n Piper<\/jats:italic>\n sp.\u2014linalool (14.6%). The minimum inhibitory concentration of\n Piper<\/jats:italic>\n essential oils against\n R. oryzae<\/jats:italic>\n ranged from 78.12 to >1250\u2009\n \u03bc<\/jats:italic>\n g\/mL. The best result of total inhibition of biofilm formation was obtained with\n Piper<\/jats:italic>\n sp. starting from 4.88\u2009\n \u03bc<\/jats:italic>\n g\/mL. Considering the bioactive potential of EOs against planktonic cells and biofilm formation of\n R. oryzae<\/jats:italic>\n could be of great interest for development of antimicrobials for therapeutic use in treatment of fungal infection.\n <\/jats:p>","DOI":"10.1155\/2018\/5295619","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T19:36:07Z","timestamp":1530819367000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Piper<\/i>\n Essential Oils Inhibit\n Rhizopus oryzae<\/i>\n Growth, Biofilm Formation, and Rhizopuspepsin Activity"],"prefix":"10.1155","volume":"2018","author":[{"given":"Catia A.","family":"Almeida","sequence":"first","affiliation":[{"name":"Department of General Microbiology, Institute of Microbiology Paulo de G\u00f3es, Federal University of Rio de Janeiro (IMPG-UFRJ), CCS Ilha do Fund\u00e3o, 21941-590 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-1206","authenticated-orcid":true,"given":"Mariana M. B.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Institute of Microbiology Paulo de G\u00f3es, Federal University of Rio de Janeiro (IMPG-UFRJ), CCS Ilha do Fund\u00e3o, 21941-590 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco C. M.","family":"Chaves","sequence":"additional","affiliation":[{"name":"EMBRAPA Western Amazon, Rodovia AM 10 km 29, 69010-970 Manaus, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Roseo de Oliveira","sequence":"additional","affiliation":[{"name":"EMBRAPA Western Amazon, Rodovia AM 10 km 29, 69010-970 Manaus, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-3991","authenticated-orcid":true,"given":"Igor A.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"School of Farmacy, Department of Natural Products and Food, Federal University of Rio de Janeiro, CCS Ilha do Fund\u00e3o, 21941-902 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto R.","family":"Bizzo","sequence":"additional","affiliation":[{"name":"EMBRAPA Food Technology, Avenida das Am\u00e9ricas 29501, 23020-470 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola E.","family":"Gama","sequence":"additional","affiliation":[{"name":"EMBRAPA Food Technology, Avenida das Am\u00e9ricas 29501, 23020-470 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela S.","family":"Alviano","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Institute of Microbiology Paulo de G\u00f3es, Federal University of Rio de Janeiro (IMPG-UFRJ), CCS Ilha do Fund\u00e3o, 21941-590 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celuta S.","family":"Alviano","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Institute of Microbiology Paulo de G\u00f3es, Federal University of Rio de Janeiro (IMPG-UFRJ), CCS Ilha do Fund\u00e3o, 21941-590 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Biological properties of essential oils from the Piper species of Brazil: a review"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-695x2009000200003"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1368441"},{"issue":"4","key":"4","first-page":"114","volume":"49","year":"1960","journal-title":"Chemist Analyst"},{"key":"5","year":"2007"},{"key":"6","year":"2002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.048504-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.11.024"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1066"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1021\/np980203p"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18011128"},{"issue":"7","key":"12","volume":"8","year":"2009","journal-title":"African Journal of 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