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There have been many studies focused on an efficient strategy to determine the optimal initial dose. Numerous clinical, genetic, and environmental factors affect the warfarin dose response. In practice, it is common that the initial warfarin dose is substantially different from the stable maintenance dose, which may increase the risk of bleeding or thrombosis prior to achieving the stable maintenance dose. In order to minimize the risk of misdosing, despite popular warfarin dose prediction models in the literature which create dose predictions solely based on patients\u2019 attributes, we have taken physicians\u2019 opinions towards the initial dose into consideration. The initial doses selected by clinicians, along with other standard clinical factors, are used to determine an estimate of the difference between the initial dose and estimated maintenance dose using shrinkage methods. The selected shrinkage method was LASSO (Least Absolute Shrinkage and Selection Operator). The estimated maintenance dose was more accurate than the original initial dose, the dose predicted by a linear model without involving the clinicians initial dose, and the values predicted by the most commonly used model in the literature, the Gage clinical model.<\/jats:p>","DOI":"10.1155\/2018\/5340845","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T19:31:49Z","timestamp":1526239909000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["A New Approach towards Minimizing the Risk of Misdosing Warfarin Initiation Doses"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-1838","authenticated-orcid":true,"given":"Ashkan","family":"Sharabiani","sequence":"first","affiliation":[{"name":"Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith A.","family":"Nutescu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Systems Outcomes and Policy and Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Galanter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Systems Outcomes and Policy and Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, USA"},{"name":"Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houshang","family":"Darabi","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9","key":"2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0735-1097(03)00416-9","volume":"41","year":"2003","journal-title":"Journal of the American College of Cardiology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.10"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809329"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.185"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.212"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2004.12.001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.162"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/560108"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044503"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-149070"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.10.1445"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr159"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.101"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.9.1331"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.9.1084"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2013.34"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/5340845.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/5340845.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/5340845.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T19:31:54Z","timestamp":1526239914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2018\/5340845\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":16,"alternative-id":["5340845","5340845"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5340845","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}