{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:22:16Z","timestamp":1761844936486,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Otolaryngology"],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:p>Meni\u00e8re\u2019s disease is a disorder of the inner ear that causes vertigo, tinnitus, fullness, and hearing loss. Several pharmacological treatments are available, but none of them has shown significant results. Betahistine has been largely used but its effect on the main symptoms of Meni\u00e8re\u2019s disease remains unclear. In order to improve clinical appropriateness and to reduce the heterogeneity of the therapeutic approaches for Meni\u00e8re\u2019s disease, we proposed a European Consensus Conference on Betahistine\u2019s prescription. A group of European experts in vestibular disorders completed a questionnaire, prepared by opinion leaders, on the use of betahistine in Meni\u00e8re\u2019s disease. The Delphi method was used as an iterative investigation method in order to increase and establish the consensus. While betahistine was considered useful to reduce the number of the vertigo attacks during the intercritical phase of the disease, its use during attacks was considered helpful only when associated with other drugs. Betahistine was not considered useful for preventing hearing loss. The experts support the use of betahistine during the intercritical phase of the disease to reduce the number and severity of vertigo episodes. They also defined the parameters for a good clinical approach to evaluate the efficacy of betahistine treatment for Meni\u00e8re\u2019s disease.<\/jats:p>","DOI":"10.1155\/2018\/5359208","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:01:37Z","timestamp":1540512097000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Good Clinical Approach: Delphi Consensus for the Use of Betahistine in Meni\u00e8re\u2019s Disease"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-9129","authenticated-orcid":true,"given":"Augusto Pietro","family":"Casani","sequence":"first","affiliation":[{"name":"Department of Surgery and Medicine, ENT Section, Pisa University Hospital, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Navari","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine, ENT Section, Pisa University Hospital, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Guidetti","sequence":"additional","affiliation":[{"name":"Vertigo Center PCM, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Lacour","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Aix-Marseille University\/CNRS, UMR 7260, F\u00e9d\u00e9ration de Recherche 3C, Centre de St Charles, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200604000-00011"},{"issue":"2","key":"2","volume":"3","year":"2013","journal-title":"BMJ Open"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0b013e32833d3164"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00019-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.5.383"},{"issue":"4","key":"8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/MAO.0b013e3181dbb7e4","volume":"31","year":"2010","journal-title":"Otology & Neurotology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3182735"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1122-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.06.015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109138535"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1288\/00005537-198408000-00020","volume":"94","year":"1984","journal-title":"The Laryngoscope"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342200.58823.6a"},{"issue":"4","key":"17","first-page":"429","volume":"3","year":"2007","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1970.04310030003002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1974.tb02314.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.4.382"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050025"},{"issue":"3","key":"22","first-page":"255","volume":"48","year":"2000","journal-title":"Neurology India"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12451"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1080\/000164800760370783"},{"issue":"3","key":"25","first-page":"24","volume":"21","year":"2001","journal-title":"Acta Otorinorhinolaryngologica Italica"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-5-32"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01795-8"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.052"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2013.00087"},{"journal-title":"Cochrane Database of Systematic Reviews","issue":"1","year":"2001","key":"30"},{"issue":"4","key":"31","first-page":"208","volume":"26","year":"2006","journal-title":"Acta Otorinorhinolaryngologica Italica"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2596-8"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0099-3964(70)90029-3"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-3287(69)80025-X"},{"issue":"544","key":"35","first-page":"8","year":"2000","journal-title":"Acta Oto-Laryngologica, Supplement"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1647-2"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/0957-4271(94)00023-U"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3233\/VES-130496"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010369241"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.05.007"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1159\/000310899"}],"container-title":["International Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijoto\/2018\/5359208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijoto\/2018\/5359208.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijoto\/2018\/5359208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T19:45:04Z","timestamp":1720727104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijoto\/2018\/5359208\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":40,"alternative-id":["5359208","5359208"],"URL":"https:\/\/doi.org\/10.1155\/2018\/5359208","relation":{},"ISSN":["1687-9201","1687-921X"],"issn-type":[{"type":"print","value":"1687-9201"},{"type":"electronic","value":"1687-921X"}],"subject":[],"published":{"date-parts":[[2018,10,25]]}}}