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The gastroprotective action of the AIG was studied in ethanol\u2010induced, pylorus ligature\u2010induced, and acetic acid\u2010induced <jats:italic>in vivo<\/jats:italic> gastric ulcer models. The enzyme\u2010linked immunoadsorbent assay (tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), prostaglandin E<jats:sub>2<\/jats:sub>(PGE<jats:sub>2<\/jats:sub>), and epidermal growth factor (EGF)), nitrate reductase assay (nitric oxide (NO)), western blot analysis (Bax, Bcl\u20102, cleaved\u2010caspase\u20103, and cleaved\u2010PARP (poly (ADP\u2010Ribose) polymerase)), histological analysis (HE), and immunohistochemical analysis (HSP\u201070, p\u2010AKT, and PCNA) were used to evaluate the anti\u2010inflammatory, antiapoptotic, and healing properties of AIG. Numerous mechanisms are involved in the antiulcer activity of AIG, including the increase of PGE<jats:sub>2<\/jats:sub>, NO, and EGF content and a reduction in TNF\u2010<jats:italic>\u03b1<\/jats:italic> levels. The upregulation of HSP\u201070, p\u2010AKT, and PCNA seems to be directly linked to the healing effect of AIG. Bax, Bcl\u20102, cleaved\u2010caspase\u20103, and cleaved\u2010PARP also play a key role in this process. The AIG exerted gastroprotective effects by reducing antisecretory, anti\u2010inflammatory, and antiapoptotic mechanisms. In addition, it promotes cell proliferation. Therefore, activation of the PI3K\/AKT signaling pathway may play an important role in cell proliferation.<\/jats:p>","DOI":"10.1155\/2018\/5498698","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T23:31:59Z","timestamp":1524007919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction"],"prefix":"10.1155","volume":"2018","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-2344","authenticated-orcid":false,"given":"Pengtao","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-703X","authenticated-orcid":false,"given":"Yanwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.005"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.08.006"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/175217"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.01.015"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.047"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v16.i9.971"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001773599"},{"key":"e_1_2_8_8_2","first-page":"463","article-title":"Experience of Professor Xu Huiyuan in Treating Chronic Gastritis","volume":"9","author":"Liu Y.","year":"2014","journal-title":"World Chinese Medicine"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(00)00007-2"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.108.217"},{"key":"e_1_2_8_11_2","first-page":"307","article-title":"Study on anti-helicobacter pylori effective fractions of modified xiao chaihu decoction","volume":"18","author":"Hu L. 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