{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:55:57Z","timestamp":1760820957200,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"foundation of the Department of Traditional Chinese Medicine of Shanghai Health Bureau","award":["2012L019B"],"award-info":[{"award-number":["2012L019B"]}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["2012L019B"],"award-info":[{"award-number":["2012L019B"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the efficacy of individualized herbal decoction with standard decoction for patients with stable bronchiectasis through N\u2010of\u20101 trials. <jats:italic>Methods<\/jats:italic>. We conducted a single center N\u2010of\u20101 trials in 17 patients with stable bronchiectasis. Each N\u2010of\u20101 trial contains three cycles. Each cycle is divided into two 4\u2010week intervention including individualized decoction and fixed decoction (control). The primary outcome was patient self\u2010reported symptoms scores on a 1\u20137 point Likert scale. Secondary outcomes were 24\u2010hour sputum volume and CAT scores. <jats:italic>Results<\/jats:italic>. Among 14 completed trials, five showed that the individualized decoction was statistically better than the control decoction on symptom scores (<jats:italic>P<\/jats:italic> &lt; 0.05) but was not clinically significant. The group data of all the trials showed that individualized decoction was superior to control decoction on symptom scores (2.13 \u00b1 0.58 versus 2.30 \u00b1 0.65, <jats:italic>P<\/jats:italic> = 0.002, mean difference and 95% CI: 0.18 (0.10, 0.25)), 24\u2009h sputum volume (<jats:italic>P<\/jats:italic> = 0.009), and CAT scores (9.69 \u00b1 4.89 versus 11.64 \u00b1 5.59, <jats:italic>P<\/jats:italic> = 0.013, mean difference and 95% CI: 1.95 (1.04, 2.86)) but not clinically significant. <jats:italic>Conclusion<\/jats:italic>. Optimizing the combined analysis of individual and group data and the improvement of statistical models may make contribution in establishing a method of evaluating clinical efficacy in line with the characteristics of traditional Chinese medicine individual diagnosis and treatment.<\/jats:p>","DOI":"10.1155\/2018\/5813767","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T23:31:20Z","timestamp":1518046280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N\u2010of\u20101 Trials"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-7115","authenticated-orcid":false,"given":"Haiyin","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suna","family":"Zi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-4021","authenticated-orcid":false,"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-3575","authenticated-orcid":false,"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-4-293"},{"key":"e_1_2_8_2_2","first-page":"3","article-title":"Potential value and feasibility of N-of-1 randomized controlled trials in research of traditional Chinese medicine","volume":"46","author":"Huang H. 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