{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:29:46Z","timestamp":1769606986375,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>High\u2010grade endometrial stromal sarcoma (HG\u2010ESS) is a rare clinical entity, particularly among young women, and only few cases have been reported in the literature. Herein, we describe the case of a 21\u2010year\u2010old woman who presented with a four\u2010month history of excessive bleeding per vagina. Endometrial curettage and cervical biopsy revealed a malignant round cell tumor suggestive of metastatic sarcoma of uterine origin. Computed tomography of the abdominopelvic region showed an enlarged uterus with diffused thickening throughout the entire endometrial cavity. Intraabdominal lymphadenopathy and ascites in the pelvic cavity were noted. The patient underwent total abdominal hysterectomy, bilateral salpingo\u2010oophorectomy, resections of the enlarged pelvic nodes, omentectomy, and biopsy of the peritoneal nodules in the cul\u2010de\u2010sac. Histological examination revealed a tumor with a permeative growth pattern composed of uniformly high\u2010grade round cells with brisk mitotic activity and extensive lymphovascular space invasion. Sections of the pelvic lymph nodes on both sides and the peritoneal nodule revealed multiple metastatic foci. Immunohistochemical studies showed positive diffuse staining for vimentin, CD 10, and cyclin D1. The pathological diagnosis was HG\u2010ESS stage IIIC. The patient experienced rapid progression of the disease while receiving adjuvant treatment and succumbed eight months after the operation. HG\u2010ESS is a rare cause of AUB in adolescents and young women but should be considered in the differential diagnosis.<\/jats:p>","DOI":"10.1155\/2018\/5906760","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:30:35Z","timestamp":1543429835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Case Report of High\u2010Grade Endometrial Stromal Sarcoma: A Rare Cause of Abnormal Uterine Bleeding in a Young Woman"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-6459","authenticated-orcid":false,"given":"Nuntasiri","family":"Eamudomkarn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwadee","family":"Itarat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilaiwan","family":"Kleebkaow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-9462","authenticated-orcid":false,"given":"Chumnan","family":"Kietpeerakool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.0014"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2009.02.003"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e3182a189ac"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000046"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath2014202829"},{"key":"e_1_2_9_6_2","first-page":"58","article-title":"Endometrial cancer in Thai women aged 45 years or younger","volume":"9","author":"Hanprasertpong J.","year":"2008","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318290cb1b"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2018.01.006"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825fa931"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824a7b1a"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.03.021"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000256"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.036"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1173"},{"key":"e_1_2_9_15_2","article-title":"High-grade endometrial stromal sarcoma in a 10-year-old girl: case report","volume":"21","author":"Wang K. 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