{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:30:02Z","timestamp":1740169802292,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771165","2016A030313295","15ykjc17b","201704030032"],"award-info":[{"award-number":["81771165","2016A030313295","15ykjc17b","201704030032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81771165","2016A030313295","15ykjc17b","201704030032"],"award-info":[{"award-number":["81771165","2016A030313295","15ykjc17b","201704030032"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["81771165","2016A030313295","15ykjc17b","201704030032"],"award-info":[{"award-number":["81771165","2016A030313295","15ykjc17b","201704030032"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology Project of Major Special Research Topics on International Collaborative Innovation","award":["81771165","2016A030313295","15ykjc17b","201704030032"],"award-info":[{"award-number":["81771165","2016A030313295","15ykjc17b","201704030032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Renal impairment increases the risk of cardiovascular events and perioperative complications in patients with heart valve disease. This study aimed to determine the perioperative benefit of statin treatment related to baseline renal function in patients with rheumatic heart disease (RHD) who had cardiac surgery.<jats:italic> Methods and Results<\/jats:italic>. We performed a retrospective study on 136 patients with RHD who underwent valve replacement surgery. The mean age of the patients was 56.2 years, 59.6% were female, 8.8% patients had diabetes mellitus, and 27.2% of patients had hypertension. Overall, 3 patients died, 2 underwent reoperation, and 25 underwent thoracentesis during the study period. For patients with renal impairment, there was a higher risk of thoracic puncture (odds ratio [OR]: 3.33; 95% confidence interval [CI]: 1.36, 8.11; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) and a longer time of drainage (difference in means: 1; 95% CI: 0.88, 1.12; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>), intensive care unit (ICU) stay (difference in means: 0.2; 95% CI: 0.17, 0.23; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>), and hospital stay (difference in means: 6.6; 95% CI: 6.15, 7.05; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) compared with normal renal function. Furthermore, statins were associated with a reduction in drainage time (difference in means: \u22121.50; 95% CI: \u22121.86, \u22121.14; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>), ICU stay (difference in means: \u22120.30; 95% CI: \u22120.40, \u22120.20; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), and hospital stay (difference in means: \u22125.40; 95% CI: \u22126.57, \u22124.23; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) in patients with renal impairment (interaction, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math> for all), but not in those with normal renal function.<jats:italic> Conclusion<\/jats:italic>. Statins have a greater clinical benefit in perioperative cardiac surgery with renal impairment. Statins are associated with a comparatively lower risk of thoracic puncture, as well as a reduced trend toward a reduction in drainage time, ICU stay, and hospital stay.<\/jats:p>","DOI":"10.1155\/2018\/5972064","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T19:31:55Z","timestamp":1523820715000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Statin Therapy Related to Baseline Renal Function in Patients with Rheumatic Heart Disease Undergoing Cardiac Surgery"],"prefix":"10.1155","volume":"2018","author":[{"given":"Rongjun","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xifeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, 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