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Forty-two periodontally healthy subjects were divided according to peri-implant condition: healthy and peri-implantitis groups. The clinical parameters as probing depth, clinical attachment level, plaque index, gingival bleeding, bleeding on probing, and suppuration were evaluated. For cytokine detection, multiplex analysis was performed, and PCR assay was used to identify herpesviruses. No significant differences were found in cytokine levels between groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The presence of herpesvirus was 1.97-fold higher in patients with peri-implantitis (odds ratio, CI 0.52\u20137.49). The association of the presence or absence of herpesvirus with the salivary markers was statistically significant for MIP-1<jats:italic>\u03b2<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0087<\/mml:mn><\/mml:math>) and TNF-<jats:italic>\u03b1<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0437<\/mml:mn><\/mml:math>) only in the peri-implantitis group. The presence of herpesviruses in patients with peri-implantitis suggests the development of a proinflammatory environment, which is characterized by increased expression of MIP-1<jats:italic>\u03b2<\/jats:italic>and TNF-<jats:italic>\u03b1<\/jats:italic>in saliva.<\/jats:p>","DOI":"10.1155\/2018\/6020625","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T23:31:39Z","timestamp":1533598299000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Jaime S.","family":"Marques Filho","sequence":"first","affiliation":[{"name":"Department of Dentistry, University Santo Amaro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gobara","sequence":"additional","affiliation":[{"name":"Department 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