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In this study, we investigated the chemical composition and evaluated the antioxidant and anti\u2010inflammatory activities of the <jats:italic>P. townsendii<\/jats:italic> ethanolic extract as well as the major isolated glycoside flavonoids tiliroside and patuletin 3\u2010O\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside. Chromatographic techniques and spectroscopic analysis were used for the isolation and identification of the major compounds. The antioxidant potential was determined through DPPH and ORAC\u2010FL assays. The total phenolic content was measured using Folin\u2010Ciocalteu reagent. The anti\u2010inflammatory activity was determined based on a model of paw edema and carrageenan\u2010 (Cg\u2010) induced pleurisy. We identified three phenolic acids, one carboxylic acid and two flavonoids, patuletin 3\u2010O\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside, and tiliroside. The ethanol crude extracts, partitions and isolated flavonoids (4581 <jats:italic>\u03bc<\/jats:italic>mol of Trolox equivalents\/g of extract in ORAC and a SC<jats:sub>50<\/jats:sub> of approximately 31.9 <jats:italic>\u03bc<\/jats:italic>g\/mL in the DPPH assay) demonstrated antioxidant activity, and the ethanolic extract as well as isolated flavonoids inhibited paw edema induced by Cg and leukocyte migration in the Cg\u2010induced pleurisy model. The extract, tiliroside, and patuletin 3\u2010O\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside obtained from <jats:italic>P. townsendii<\/jats:italic> have therapeutic potential against oxidative stress\u2010related and inflammatory disorders.<\/jats:p>","DOI":"10.1155\/2018\/6057579","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T23:32:00Z","timestamp":1538350320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Anti\u2010Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3\u2010O\u2010<i>\u03b2<\/i>\u2010D\u2010Glucopyranoside from <i>Pfaffia townsendii<\/i> (Amaranthaceae)"],"prefix":"10.1155","volume":"2018","author":[{"given":"Wallace Ribeiro","family":"Corr\u00eaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Freitas","family":"Serain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Aranha Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane V. 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