{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:13:39Z","timestamp":1773526419040,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nanjing Medical Science and Technology Development Project","award":["YKK16274"],"award-info":[{"award-number":["YKK16274"]}]},{"name":"Nanjing Medical Science and Technology Development Project","award":["2242017K40273"],"award-info":[{"award-number":["2242017K40273"]}]},{"name":"Fundamental Research Funds of the Central Universities","award":["YKK16274"],"award-info":[{"award-number":["YKK16274"]}]},{"name":"Fundamental Research Funds of the Central Universities","award":["2242017K40273"],"award-info":[{"award-number":["2242017K40273"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Tinnitus is believed to result from the maladaptive plasticity of the auditory nervous system; reports regarding its severity and prognosis are conflicting. We evaluated the characteristic and short-term prognosis of tinnitus associated with sudden sensorineural hearing loss (SSNHL). A total of 230 cases were enrolled. The severity and 1-month prognosis of tinnitus (according to the Tinnitus Handicap Inventory (THI)) were assessed in terms of the patients\u2019 sex, age, level of hearing loss, type of audiogram results, and so on. According to our statistical analysis, the degree of handicap due to tinnitus was not related to sex, age, or level of hearing loss; the Tinnitus Handicap Inventory indicated that the low-frequency-audiogram group had a low tinnitus handicap (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>F<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>7.516<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>). Furthermore, we found that the prognosis of tinnitus was not related to the type of audiogram or level of hearing loss. Recovery from a severe level of hearing loss was, however, found to be associated with a poor tinnitus prognosis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>F<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>5.203<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:math>). In summary, our study indicates that the association between tinnitus and SSNHL is extremely high. Tinnitus can be ameliorated by the successful treatment of hearing loss. The study was registered in the Chinese Clinical Trial Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showprojen.aspx?proj=25256\">ChiCTR1800014797<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2018\/6059697","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T19:32:18Z","timestamp":1526239938000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["The Characteristic and Short-Term Prognosis of Tinnitus Associated with Sudden Sensorineural Hearing Loss"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-7389","authenticated-orcid":true,"given":"Xiaoqiong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Zhongda Hospital, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 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