{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:58:27Z","timestamp":1788353907461,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. IgG4-related disease (IgG4-RD) is a fibroinflammatory condition. T-cells play a crucial role in the pathogenesis, and therefore, serum soluble interleukin-2 receptor (sIL-2R) may be a potential biomarker. <jats:italic>Method<\/jats:italic>. We studied the levels of sIL-2R in 26 histologically proven IgG4-RD patients with available serum sIL-2R and compared them to those in newly diagnosed and untreated sarcoidosis patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>78<\/mml:mn><\/mml:math>) and controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>101<\/mml:mn><\/mml:math>) and the serum sIL-2R levels in patients after treatment of IgG4-RD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>15<\/mml:mn><\/mml:math>). The disease activity was measured using the IgG4-Related Disease Responder Index (IgG4-RD RI). <jats:italic>Results<\/jats:italic>. Median serum sIL-2R in IgG4-RD patients was 4667\u2009pg\/ml compared to 1515\u2009pg\/ml in controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and 6050\u2009pg\/ml in sarcoidosis patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math> compared to IgG4-RD). All IgG4-RD patients had elevated serum sIL-2R levels compared to the reference value of &lt;2500\u2009pg\/ml in controls and 85% elevated serum IgG4; however, these did not correlate with each other. Both serum sIL-2R and IgG4 levels declined significantly after treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>, resp.). Before treatment, serum sIL-2R level and IgG4-RD RI did not correlate with each other. However, the decrease in serum sIL-2R upon treatment did correlate significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>) with the decrease in disease activity assessed by IgG-RD RI. <jats:italic>Conclusion<\/jats:italic>. Serum sIL-2R is elevated in IgG4-RD reflecting the inflammatory process with enhanced T-cell activation. Furthermore, serum sIL-2R might serve as a potential marker of response to treatment in IgG4-RD.<\/jats:p>","DOI":"10.1155\/2018\/6103064","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T18:33:46Z","timestamp":1519929226000},"page":"1-6","source":"Crossref","is-referenced-by-count":35,"title":["Soluble Interleukin-2 Receptor: A Potential Marker for Monitoring Disease Activity in IgG4-Related Disease"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-7712","authenticated-orcid":true,"given":"A. F.","family":"Karim","sequence":"first","affiliation":[{"name":"Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E. M.","family":"Eurelings","sequence":"additional","affiliation":[{"name":"Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Bansie","sequence":"additional","affiliation":[{"name":"Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"van Hagen","sequence":"additional","affiliation":[{"name":"Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"},{"name":"Section Clinical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. M.","family":"van Laar","sequence":"additional","affiliation":[{"name":"Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"},{"name":"Section Clinical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Dik","sequence":"additional","affiliation":[{"name":"Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"1","first-page":"110","volume":"74","year":"2016","journal-title":"The Netherlands Journal of Medicine"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60720-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13376"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0079-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1614275"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex171"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12641"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1330"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.024"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/art.39209"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1159\/000312125"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1159\/000337761"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.236"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/all.12342"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.08.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209139"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.5.97-02050"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13792"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.121"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2764261"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv092"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.891964"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"24","volume":"2012","year":"2012","journal-title":"International Journal of Rheumatology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00161-8"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.990674"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212110"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nri3156"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1251818"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/6103064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/6103064.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2018\/6103064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T18:33:46Z","timestamp":1519929226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2018\/6103064\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"alternative-id":["6103064","6103064"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6103064","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}