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Global mean normalization (GMN) of PET data reveals disease-based differences from healthy individuals as fractional changes across regions relative to a global mean. To assess the impact of GMN applied to metabolic data, we compared CMR<jats:sub>glc<\/jats:sub> with and without GMN in healthy awake volunteers with eyes closed (i.e., control) against specific physiological\/clinical states, including healthy\/awake with eyes open, healthy\/awake but congenitally blind, healthy\/sedated with anesthetics, and patients with disorders of consciousness. Without GMN, global CMR<jats:sub>glc<\/jats:sub> alterations compared to control were detected in all conditions except in congenitally blind where regional CMR<jats:sub>glc<\/jats:sub> variations were detected in the visual cortex. However, GMN introduced regional and bidirectional CMR<jats:sub>glc<\/jats:sub> changes at smaller fractions of the quantitative delocalized changes. While global information was lost with GMN, the quantitative approach (i.e., a validated method for quantitative baseline metabolic activity without GMN) not only preserved global CMR<jats:sub>glc<\/jats:sub> alterations induced by opening eyes, sedation, and varying consciousness but also detected regional CMR<jats:sub>glc<\/jats:sub> variations in the congenitally blind. These results caution the use of GMN upon PET-measured CMR<jats:sub>glc<\/jats:sub> data in health and disease.<\/jats:p>","DOI":"10.1155\/2018\/6120925","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T19:31:12Z","timestamp":1528831872000},"page":"1-16","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain"],"prefix":"10.1155","volume":"2018","author":[{"given":"Kristian N.","family":"Mortensen","sequence":"first","affiliation":[{"name":"Department of Radiology & Biomedical Imaging and Magnetic Resonance Research Center, Yale University, New Haven, CT, USA"},{"name":"Department of Neuroscience, University of Copenhagen, Copenhagen, 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