{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:19:35Z","timestamp":1775841575124,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Leukaemia is a form of blood cancer which affects the white blood cells and damages the bone marrow. Usually complete blood count (CBC) and bone marrow aspiration are used to diagnose the acute lymphoblastic leukaemia. It can be a fatal disease if not diagnosed at the earlier stage. In practice, manual microscopic evaluation of stained sample slide is used for diagnosis of leukaemia. But manual diagnostic methods are time-consuming, less accurate, and prone to errors due to various human factors like stress, fatigue, and so forth. Therefore, different automated systems have been proposed to wrestle the glitches in the manual diagnostic methods. In recent past, some computer-aided leukaemia diagnosis methods are presented. These automated systems are fast, reliable, and accurate as compared to manual diagnosis methods. This paper presents review of computer-aided diagnosis systems regarding their methodologies that include enhancement, segmentation, feature extraction, classification, and accuracy.<\/jats:p>","DOI":"10.1155\/2018\/6125289","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T18:41:50Z","timestamp":1519843310000},"page":"1-13","source":"Crossref","is-referenced-by-count":43,"title":["Computer-Aided Diagnosis of Acute Lymphoblastic Leukaemia"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7213-6447","authenticated-orcid":true,"given":"Sarmad","family":"Shafique","sequence":"first","affiliation":[{"name":"Department of Computer Science, Bahria University, Islamabad, Pakistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-0752","authenticated-orcid":true,"given":"Samabia","family":"Tehsin","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Bahria University, Islamabad, Pakistan"}]}],"member":"311","reference":[{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.COT.0000466405.48815.5b"},{"issue":"11","key":"5","first-page":"6466","volume":"2","year":"2014","journal-title":"International Journal of Innovative Research in Computer"},{"issue":"2","key":"7","volume":"1","year":"2013","journal-title":"International Journal of Innovative Research in Computer and Communication Engineering"},{"issue":"2","key":"9","first-page":"3","volume":"9","year":"2015","journal-title":"International Journal of Computer Engineering and Applications"},{"issue":"3","key":"10","first-page":"148","volume":"4","year":"2013","journal-title":"International Journal of Electronics and Communication Engineering & Technology (IJECET)"},{"issue":"9","key":"11","first-page":"231","volume":"5","year":"2016","journal-title":"International Journal of Scientific & Technology Research"},{"issue":"5","key":"12","first-page":"1843","volume":"2","year":"2013","journal-title":"International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2016.11.021"},{"issue":"1","key":"67","volume":"4","year":"2017","journal-title":"International Journal of Advanced Research in Science, Engineering and Technology"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1007\/s11042-017-4478-3"},{"issue":"3","key":"27","volume":"2","year":"2013","journal-title":"International Journal of Emerging Trends & Technology in Computer Science (IJETTCS)"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9514707"},{"key":"69","first-page":"49","year":"2015","journal-title":"Journal of Medical Signals and Sensors"},{"issue":"4","key":"70","first-page":"38","volume":"6","year":"2017","journal-title":"International Journal of Advanced Research in Computer Science and Electronics Engineering (IJARCSEE)"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.9790\/0661-16537987"},{"issue":"1","key":"71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/2228-7477.150428","volume":"5","year":"2015","journal-title":"Journal of Medical Signals and Sensors"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22718"},{"key":"76","first-page":"1887","year":"2014","journal-title":"Neural Computing and Applications"},{"issue":"3","key":"77","first-page":"128","volume":"2","year":"2015","journal-title":"Frontiers in Biomedical Technologies"},{"key":"30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.artmed.2017.05.003","volume":"78","year":"2017","journal-title":"Artificial Intelligence in Medicine"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1007\/s12575-009-9011-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.14569\/ijacsa.2013.040406"},{"issue":"2","key":"20","first-page":"89","volume":"2","year":"2013","journal-title":"International Journal of Emerging Trends & Technology in Computer Science (IJETTCS)"},{"issue":"3","key":"22","first-page":"171","volume":"3","year":"2013","journal-title":"International Journal of Engineering and Innovative Technology (IJEIT)"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1166\/jmihi.2012.1101"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8655(97)00131-1"},{"issue":"2","key":"34","first-page":"7253","volume":"3","year":"2014","journal-title":"International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering"},{"issue":"4","key":"35","volume":"2","year":"2011","journal-title":"International Journal of Research and Reviews in Computer Science (IJRRCS)"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3844\/ajassp.2012.615.619"},{"issue":"8","key":"39","volume":"2","year":"2014","journal-title":"International Journal of Electrical, Electronics and Data Communication"},{"issue":"2","key":"40","volume":"9","year":"2015","journal-title":"International Journal Of Computer Engineering & Applications"},{"issue":"1","key":"41","volume":"3","year":"2015","journal-title":"International Journal of Computer Science Trends and Technology (IJCST)"},{"issue":"4","key":"42","first-page":"42","volume":"6","year":"2017","journal-title":"International Journal of Latest Technology in Engineering, Management &amp; Applied Science (IJLTEMAS)"},{"issue":"6","key":"44","first-page":"119","volume":"9","year":"2017","journal-title":"Digital Image Processing"},{"key":"46","first-page":"74","volume":"1","year":"2013","journal-title":"Journal of Network and Innovative Computing"},{"issue":"4","key":"48","first-page":"995","volume":"5","year":"2016","journal-title":"International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering"},{"issue":"1","key":"49","volume":"5","year":"2015","journal-title":"International Journal of Advanced Research in Computer Science and Software Engineering"},{"issue":"3","key":"50","volume":"3","year":"2015","journal-title":"Journal of Innovative Research in Computer and Communication Engineering"},{"issue":"4","key":"53","first-page":"192","volume":"3","year":"2016","journal-title":"International Journal for Innovative Research in Science & Technology"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/AMM.43.744"},{"issue":"4","key":"60","volume":"4","year":"2017","journal-title":"International Journal for Research in Technological Studies"},{"issue":"2","key":"62","first-page":"94","volume":"5","year":"2017","journal-title":"International Journal on Recent and Innovation Trends in Computing and Communication"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130805"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-014-1200-8"},{"issue":"3","key":"65","first-page":"1460","volume":"4","year":"2017","journal-title":"International Research Journal of Engineering and Technology (IRJET)"},{"issue":"1","key":"66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/2228-7477.108171","volume":"2","year":"2012","journal-title":"Journal of Medical Signals and Sensors"},{"issue":"6","key":"81","first-page":"6888","volume":"10","year":"2015","journal-title":"ARPN Journal of Engineering and Applied Sciences"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-015-0037-1"},{"issue":"4","key":"84","volume":"10","year":"2013","journal-title":"International Arab Journal of Information Technolog"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6125289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6125289.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6125289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T22:17:31Z","timestamp":1570832251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2018\/6125289\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":49,"alternative-id":["6125289","6125289"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6125289","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}