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Currently, direct-acting antiviral drugs (DAA) are the gold standard for treating HCV infection, while yielding SVR in nearly all patients. In chronic HCV patients with T2DM (prediabetes most likely too), DAA therapy is associated with both better fasting glucose and glycated hemoglobin (HbA1C) controls; thus reducing pharmacotherapy in a certain part of patients is possible. Papers mentioned in the review confirmed DAA role in both total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) increase. This alteration was accompanied by an increase in high-density lipoprotein cholesterol (HDL-C) and a decrease in triglycerides (TG) verified by most of the studies. However, the clinical significance of lipoprotein alterations caused by DAA therapy has not been explained yet. Moreover, DAA treatment of chronic hepatitis C improves hypertension control and atherosclerotic plaques. It is very likely that DAA therapeutic regimens will decrease both T2DM prevalence and cardiovascular risk in chronic hepatitis C patients; further research, however, is needed.<\/jats:p>","DOI":"10.1155\/2018\/6150861","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T19:33:34Z","timestamp":1534188814000},"page":"1-11","source":"Crossref","is-referenced-by-count":48,"title":["Chronic Hepatitis C Association with Diabetes Mellitus and Cardiovascular Risk in the Era of DAA Therapy"],"prefix":"10.1155","volume":"2018","author":[{"given":"Sylvia","family":"Drazilova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Poprad, Poprad, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Gazda","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, Kosice, 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