{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:01:34Z","timestamp":1740153694841,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010447","name":"Ministry of Research, Technology and Higher Education of the Republic of Indonesia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Otolaryngology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chronic suppurative otitis media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment especially in developing countries. The role of Mannose-Binding Lectin (MBL), a component of innate immunity, in CSOM has not been studied. The aim of the study was to examine whether MBL deficiency was more frequently present in cases group of tubotympanic CSOM patients rather than healthy subjects.<jats:italic> Material and Methods<\/jats:italic>. This was an analytic observational study. Subjects were enrolled in the Otorhinolaryngology Clinic at Margono Soekarjo Hospital, Purwokerto, Indonesia. An independent <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:math>-test was used to compare the mean of MBL serum concentration between tubotympanic CSOM subjects and control.<jats:italic> Results<\/jats:italic>. From 36 tubotympanic CSOM patients, there were 8 (22.22%) patients with MBL deficiency (MBL level &lt; 100\u2009ng\/ml), while no deficiency was found in the control group. The mean of MBL level in cases group was 354.88\u2009ng\/ml, with the lowest level being 0.001\u2009ng\/ml and the highest level 690.24\u2009ng\/ml, while in the control group MBL level mean was 376.27 with the lowest level being 188.71 and the highest level 794.54\u2009ng\/ml.<jats:italic> Conclusion<\/jats:italic>. There was no significant difference of MBL serum level between tubotympanic CSOM and control group. However, the presence of subjects with MBL deficiency in the tubotympanic CSOM group might be considered as playing a role in the tubotympanic CSOM.<\/jats:p>","DOI":"10.1155\/2018\/6178159","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T23:33:21Z","timestamp":1527032001000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6054-4438","authenticated-orcid":true,"given":"Anton Budhi","family":"Darmawan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Jenderal Soedirman-Margono Soekarjo Hospital, Purwokerto, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsetyawan H. N. 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