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(GS) is often accompanied by recurrent respiratory infections and chronic diarrhea. The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection. Twenty healthy volunteers were recruited as healthy controls (HCs). Flow cytometry was applied to determine the proportions of circuiting CD4<jats:sup>+<\/jats:sup> T cells, CD8<jats:sup>+<\/jats:sup> T cells, <jats:italic>\u03b3\u03b4<\/jats:italic>T cells, and regulatory T (Treg) cells in our GS patient. We also examined the proliferation capability of ex vivo CD4<jats:sup>+<\/jats:sup> T cells and detected the levels of cytokines interferon- (IFN-) <jats:italic>\u03b3<\/jats:italic> and interleukin-17A secreted by ex vivo immune cells from this GS patient. Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> cells, and more Treg cells in his peripheral blood. Additionally, the patient\u2019s V<jats:italic>\u03b4<\/jats:italic>2 T cell levels were significantly decreased despite having a normal percentage of <jats:italic>\u03b3\u03b4<\/jats:italic>T cells. Ex vivo peripheral CD4<jats:sup>+<\/jats:sup> T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1. Moreover, IFN-<jats:italic>\u03b3<\/jats:italic> was predominantly derived from CD8<jats:sup>+<\/jats:sup> T cells in this GS patient, rather than from CD4<jats:sup>+<\/jats:sup> T cells and <jats:italic>\u03b3\u03b4<\/jats:italic>T cells. This GS patient had impaired T and B cell immunological alternations and cytokine disruptions after thymectomy. Detailed research should focus on therapies that can adjust the immune status in such patients for a better outcome.<\/jats:p>","DOI":"10.1155\/2018\/6212410","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T23:32:10Z","timestamp":1524526330000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Aberrant Peripheral Immune Function in a Good Syndrome Patient"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5234-5268","authenticated-orcid":true,"given":"Xian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"},{"name":"National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, 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