{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:09:57Z","timestamp":1789427397101,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2018,9,10]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) is responsible for one of the most common infections in the world. The prevalence exceeds 50% of the population in developing countries, and approximately one-third of the adults are colonized in North Europe and North America. It is considered a major pathogenic agent of chronic gastritis, peptic ulcer, atrophic gastritis, gastric cancer, and mucosa-associated lymphoid tissue lymphoma (MALT). <jats:italic>Hp<\/jats:italic> colonization modifies the composition of gastric microbiota that could drive the development of gastric disorders. Currently, an emerging problem in <jats:italic>Hp<\/jats:italic> treatment is represented by the increasing rate of antimicrobial therapy resistance. In this context, the search for adjuvant agents can be very useful to overcome this issue and probiotics administration can represent a valid option. The aim of this review is to describe the gastric microbiota changes during <jats:italic>Hp<\/jats:italic> colonization, the mechanisms of action, and a possible role of probiotics in the treatment of this infection.<\/jats:p>","DOI":"10.1155\/2018\/6237239","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T19:31:01Z","timestamp":1536607861000},"page":"1-7","source":"Crossref","is-referenced-by-count":28,"title":["<i>Helicobacter pylori<\/i> Infection and Gastric Dysbiosis: Can Probiotics Administration Be Useful to Treat This Condition?"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-2018","authenticated-orcid":true,"given":"Giovanni","family":"Bruno","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Zaccari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Porowska","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic, Vascular Surgery and Transplants, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-3088","authenticated-orcid":true,"given":"Maria Teresa","family":"Mascellino","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Severi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00054-05"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12165"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12233"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-002-0019-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00011-10"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"9","year":"2001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02868.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.403s"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.113779"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12807"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(84)91816-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02000.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.03.016"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26205"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312904"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614566846"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400731"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307595"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/bf01296784"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02508"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006653"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002836"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.243"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12335"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2015.06.002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v7.i1.97"},{"issue":"1","key":"30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","volume":"66","year":"2017","journal-title":"Gut"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/s1521-6918(03)00070-2"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695x.2011.00865.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/740381"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1159\/000051865"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1159\/000007660"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg227"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.5.709"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00885.x"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.003"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2010.0090"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00751.x"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13214"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i43.6302"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e318266f6cf"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615617358"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s117886"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i3.673"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-015-0124-6"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i45.7952"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2291-6"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-013-1490-2"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028x-66.1.3"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00683"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12021"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1007\/s10123-002-0063-2"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(98)00481-x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009407-0"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695x.2002.tb00541.x"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.01.017"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i21.6561"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12237"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/6237239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/6237239.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/6237239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T19:35:18Z","timestamp":1539200118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjidmm\/2018\/6237239\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":61,"alternative-id":["6237239","6237239"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6237239","relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]}}}