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Intervention strategies using plant\u2010derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges. Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement. Here, we have summarized the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of NDs. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen\u2010activated protein kinase cascade, downregulation of mRNA expression of PD\u2010linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes. Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of NDs.<\/jats:p>","DOI":"10.1155\/2018\/6241017","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T23:40:26Z","timestamp":1530142826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":409,"title":["Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-5220","authenticated-orcid":false,"given":"Adaze Bijou","family":"Enogieru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-6663","authenticated-orcid":false,"given":"William","family":"Haylett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donavon Charles","family":"Hiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Bardien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-7499","authenticated-orcid":false,"given":"Okobi Eko","family":"Ekpo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.030205"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp223"},{"key":"e_1_2_7_3_2","volume-title":"Global Burden of Disease","author":"WHO","year":"2004"},{"key":"e_1_2_7_4_2","first-page":"78","article-title":"Current concepts of neurodegenerative diseases","volume":"2","author":"Kovacs G. 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