{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:54:57Z","timestamp":1761490497804,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["15JCZDJC34900","31070797"],"award-info":[{"award-number":["15JCZDJC34900","31070797"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["15JCZDJC34900","31070797"],"award-info":[{"award-number":["15JCZDJC34900","31070797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Our previous studies showed that<jats:italic>\u03b3\u03b4<\/jats:italic>T cells provided immune protection against Chlamydial<jats:italic>muridarum<\/jats:italic>(Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung<jats:italic>\u03b3\u03b4<\/jats:italic>T cell subsets, specifically the IL-17 and IFN<jats:italic>\u03b3<\/jats:italic>production by them following Cm lung infection. Our results found that five<jats:italic>\u03b3\u03b4<\/jats:italic>T cell subsets, V<jats:italic>\u03b3<\/jats:italic>1+ T, V<jats:italic>\u03b3<\/jats:italic>2+ T, V<jats:italic>\u03b3<\/jats:italic>4+ T, V<jats:italic>\u03b3<\/jats:italic>5+ T, and V<jats:italic>\u03b3<\/jats:italic>6+ T, expressed in lungs of na\u00efve mice, while Cm lung infection mainly induced the proliferation and activation of V<jats:italic>\u03b3<\/jats:italic>4+ T cells at day 3 p.i., following V<jats:italic>\u03b3<\/jats:italic>1+ T cells at day 7 p.i. Cytokine detection showed that Cm lung infection induced IFN<jats:italic>\u03b3<\/jats:italic>secretion firstly by V<jats:italic>\u03b3<\/jats:italic>4+ T cells at very early stage (day 3) and changed to V<jats:italic>\u03b3<\/jats:italic>1+ T cells at midstage (day 7). Furthermore, V<jats:italic>\u03b3<\/jats:italic>4+ T cell is the main<jats:italic>\u03b3\u03b4<\/jats:italic>T cell subset that secretes IL-17 at the very early stage of Cm lung infection and V<jats:italic>\u03b3<\/jats:italic>1+ T cell did not secrete IL-17 during the infection. These findings provide in vivo evidence that V<jats:italic>\u03b3<\/jats:italic>4+T cells are the major IL-17 and IFN<jats:italic>\u03b3<\/jats:italic>-producing<jats:italic>\u03b3\u03b4<\/jats:italic>T cell subsets at the early period of Cm lung infection.<\/jats:p>","DOI":"10.1155\/2018\/6265746","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T23:31:40Z","timestamp":1518996700000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["V<i>\u03b3<\/i>4+ T Cells: A Novel IL-17-Producing<i>\u03b3\u03b4<\/i>T Subsets during the Early Phase of Chlamydial Airway Infection in Mice"],"prefix":"10.1155","volume":"2018","author":[{"given":"Li-da","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin 300070, 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