{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:59Z","timestamp":1790041319963,"version":"4.0.1"},"reference-count":239,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO). After being merely regarded as a toxic poisonous molecule, it is now recognized that mammalian cells are equipped with sophisticated enzymatic systems for H\n                    <jats:sub>2<\/jats:sub>\n                    S production and breakdown. The signaling role of H\n                    <jats:sub>2<\/jats:sub>\n                    S is mainly related to its ability to modify different protein targets, particularly by promoting persulfidation of protein cysteine residues and by interacting with metal centers, mostly hemes. H\n                    <jats:sub>2<\/jats:sub>\n                    S has been shown to regulate a myriad of cellular processes with multiple physiological consequences. As such, dysfunctional H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism is increasingly implicated in different pathologies, from cardiovascular and neurodegenerative diseases to cancer. As a highly diffusible reactive species, the intra\u2010 and extracellular levels of H\n                    <jats:sub>2<\/jats:sub>\n                    S have to be kept under tight control and, accordingly, regulation of H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism occurs at different levels. Interestingly, even though H\n                    <jats:sub>2<\/jats:sub>\n                    S, NO, and CO have similar modes of action and parallel regulatory targets or precisely because of that, there is increasing evidence of a crosstalk between the three gasotransmitters. Herein are reviewed the biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO.\n                  <\/jats:p>","DOI":"10.1155\/2018\/6290931","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T19:40:53Z","timestamp":1530128453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5301-0681","authenticated-orcid":false,"given":"Alessandro","family":"Giuffr\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-8280","authenticated-orcid":false,"given":"Jo\u00e3o B.","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"De Morbis Artificum Diatriba","author":"Ramazzini B.","year":"1713"},{"key":"e_1_2_9_2_2","volume-title":"Chemische Abhandlung von der Luft und dem Feuer","author":"Scheele C. 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