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Recently, the blood-brain barrier is considered as a \u201cneuro-glia-vascular unit,\u201d a structural and functional compound composed of capillary endothelial cells, glial cells, pericytes, and neurons, which plays a pivotal role in maintaining the balance of the microenvironment in and out of the brain. Tight junctions and adherens junctions, which function as barriers of the blood-brain barrier, are two well-known kinds in the endothelial cell junctions. In this review, we focus on the less-concerned contribution of gap junction proteins, connexins in blood-brain barrier integrity under physio-\/pathology conditions. In the neuro-glia-vascular unit, connexins are expressed in the capillary endothelial cells and prominent in astrocyte endfeet around and associated with maturation and function of the blood-brain barrier through a unique signaling pathway and an interaction with tight junction proteins. Connexin hemichannels and connexin gap junction channels contribute to the physiological or pathological progress of the blood-brain barrier; in addition, the interaction with other cell-cell-adhesive proteins is also associated with the maintenance of the blood-brain barrier. Lastly, we explore the connexins and connexin channels involved in the blood-brain barrier in neurological diseases and any programme for drug discovery or delivery to target or avoid the blood-brain barrier.<\/jats:p>","DOI":"10.1155\/2018\/6323901","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T19:32:24Z","timestamp":1528659144000},"page":"1-13","source":"Crossref","is-referenced-by-count":44,"title":["Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yinan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguo","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China 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