{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:22:46Z","timestamp":1773598966349,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Modern orthopaedic surgery provides a variety of techniques for cartilage repair. The Autologous Matrix-Induced Chondrogenesis (AMIC) procedure is a single-step technique with a collagen I\/III scaffold for the treatment of full-thickness cartilage lesions. The aim of the study was to analyze the outcome of the AMIC procedure in overweight patients with knee cartilage defects. Overweight patients treated with AMIC surgery were followed up by clinical and MRI examination. 9 patients with a cartilage defect of the knee with a mean lesion size of <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">2<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1<\/mml:mn><mml:mtext>.<\/mml:mtext><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math>\u2009cm<jats:sup>2<\/jats:sup> and an average body mass index (BMI) of 29.3 were available for the follow-up. The Lysholm Score was significantly improved by the AMIC procedure (38 to 67, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.008<\/mml:mn><\/mml:math>). The VAS Score was significantly lower after the procedure (9 to 3, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.018<\/mml:mn><\/mml:math>). In the postoperative MOCART Scale, the scaffold reached defect covering of 80%. However, 2 patients had to be revised due to persisting knee pain. The AMIC procedure enhances pain reduction and gain of knee function for cartilage defects of overweight patients. However, in cases of an increased BMI, the patient had to be informed that success rate is reduced despite good defect covering.<\/jats:p>","DOI":"10.1155\/2018\/6363245","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T19:33:56Z","timestamp":1525808036000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Cartilage Surgery in Overweight Patients: Clinical and MRI Results after the Autologous Matrix-Induced Chondrogenesis Procedure"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-7381","authenticated-orcid":true,"given":"Matthias","family":"Lahner","sequence":"first","affiliation":[{"name":"Joint Center Hilden, Hilden, Germany"},{"name":"Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ull","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Berufsgenossenschaftliches Universit\u00e4tsklinikum Bergmannsheil, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Hagen","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"von Schulze Pellengahr","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Bochum, Germany"},{"name":"Agaplesion Ev. Bathildiskrankenhaus, Bad Pyrmont, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiriakos","family":"Daniilidis","sequence":"additional","affiliation":[{"name":"Orthop\u00e4die Traumatologie Centrum (OTC), Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Victor","family":"von Engelhardt","sequence":"additional","affiliation":[{"name":"Faculty of Health, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Teske","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Bochum, Germany"},{"name":"Kath. 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