{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T13:47:52Z","timestamp":1777211272723,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:00:00Z","timestamp":1524355200000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["316023-05-2-CG000"],"award-info":[{"award-number":["316023-05-2-CG000"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K17270"],"award-info":[{"award-number":["K17270"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Aster koraiensis<\/jats:italic> extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age\u2010related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen\u2010induced retinopathy (OIR)<jats:italic>.<\/jats:italic> Vascular endothelial growth factor\u2010 (VEGF\u2010) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL\/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50\u2009mg\/kg\/day) and CA (25 and 50\u2009mg\/kg\/day) were administered intraperitoneally for 5 days (P12\u2013P16). Retinal flat mounts were prepared to measure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1\u201310\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) resulted in the inhibition of VEGF\u2010mediated tube formation in a dose\u2010dependent manner. The neovascular area was significantly smaller in AKE or CA\u2010treated mice than in the vehicle\u2010treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA.<\/jats:p>","DOI":"10.1155\/2018\/6402650","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T23:31:52Z","timestamp":1524439912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Aster koraiensis<\/i> Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen\u2010Induced Retinopathy"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-2158","authenticated-orcid":false,"given":"Junghyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wookwon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Bin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-9887","authenticated-orcid":false,"given":"Chan-Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-8220","authenticated-orcid":false,"given":"Jin Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801537"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-0993-5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000268033"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.079"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00085-X"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0077-9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0300-y"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945011794182674"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31819d2591"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181884fd2"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.107"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680802492440"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/206837"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01227"},{"key":"e_1_2_8_15_2","volume-title":"Illustrated Book of Korean Medicinal Herbs","author":"Ahn D. K.","year":"1998"},{"key":"e_1_2_8_16_2","first-page":"627","article-title":"Effect of plant growth regulators on growth and flowering of potted Lychnis cognata, Aster koraiensis, and Campanula takesimana","volume":"38","author":"KO J. Y.","year":"1996","journal-title":"RDA Journal of Agricultural Science"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.129"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8090585"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/245271"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1216-8"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600946724"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2008.00305.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/359843a0"},{"key":"e_1_2_8_24_2","first-page":"290","article-title":"Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity","volume":"37","author":"Stone J.","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(66)91322-5"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(57)90426-9"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.3"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312203"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140410008"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0825-4"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2397"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534735405285562"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0089"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3533"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6496"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5524"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1568702"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf026187q"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0402429"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-120003407"},{"key":"e_1_2_8_41_2","first-page":"895","article-title":"The antitumor activities of flavonoids","volume":"19","author":"Kandaswami C.","year":"2005","journal-title":"In Vivo"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.3.163"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-014-0216-2"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/6402650.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/6402650.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/6402650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:27:49Z","timestamp":1722918469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/6402650"}},"subtitle":[],"editor":[{"given":"Gabino","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/6402650"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6402650","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6402650"}}