{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:31Z","timestamp":1790254291699,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Edward G. Schlieder Endowment","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}]},{"name":"Edward G. Schlieder Endowment","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}]},{"name":"Edward G. Schlieder Endowment","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}]},{"name":"Edward G. Schlieder Endowment","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}]},{"name":"Edward G. Schlieder Endowment","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}]},{"name":"Edward G. Schlieder Endowment","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}]},{"name":"Edward G. Schlieder Endowment","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}]},{"name":"Franklin D. Dickson\/Missouri Endowment","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG055373"],"award-info":[{"award-number":["U19AG055373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109068"],"award-info":[{"award-number":["R01GM109068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107354"],"award-info":[{"award-number":["R01MH107354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781"],"award-info":[{"award-number":["R01AR059781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:p>Osteoporosis is a serious public health issue, which is mostly characterized by low bone mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. Single nucleotide polymorphisms (SNPs) that introduce or disrupt CpG dinucleotides (CpG-SNPs) may alter DNA methylation levels and thus represent strong candidate functional variants. Here, we performed a targeted GWAS for 63,627 potential functional CpG-SNPs that may affect DNA methylation in bone-related cells, in five independent cohorts (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>5905<\/mml:mn><\/mml:math>). By meta-analysis, 9 CpG-SNPs achieved a genome-wide significance level (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>7.86<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>7<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>) for association with lumbar spine BMD and additional 15 CpG-SNPs showed suggestive significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>5.00<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>5<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>) association, of which 2 novel SNPs <jats:italic>rs7231498 (NFATC1)<\/jats:italic> and <jats:italic>rs7455028 (ESR1)<\/jats:italic> also reached a genome-wide significance level in the joint analysis. Several identified CpG-SNPs were mapped to genes that have not been reported for association with BMD in previous GWAS, such as <jats:italic>NEK3<\/jats:italic> and <jats:italic>NFATC1<\/jats:italic> genes, highlighting the enhanced power of targeted association analysis for identification of novel associations that were missed by traditional GWAS. Interestingly, several genomic regions, such as <jats:italic>NEK3<\/jats:italic> and <jats:italic>LRP5<\/jats:italic> regions, contained multiple significant\/suggestive CpG-SNPs for lumbar spine BMD, suggesting that multiple neighboring CpG-SNPs may synergistically mediate the DNA methylation level and gene expression pattern of target genes. Furthermore, functional annotation analyses suggested a strong regulatory potential of the identified BMD-associated CpG-SNPs and a significant enrichment in biological processes associated with protein localization and protein signal transduction. Our results provided novel insights into the genetic basis of BMD variation and highlighted the close connections between genetic and epigenetic mechanisms of complex disease.<\/jats:p>","DOI":"10.1155\/2018\/6407257","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T19:31:09Z","timestamp":1533670269000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-9229","authenticated-orcid":true,"given":"Chuan","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, New Orleans 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-6064","authenticated-orcid":true,"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, New Orleans 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, New Orleans 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, New Orleans 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, New Orleans 70112, USA"},{"name":"School of Basic Medical Science, Central South University, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08761-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2269"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1449506"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0044"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nature14878"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt575"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1796"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2249"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S16748"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000806"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3949"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.073"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2687"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.186"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.021"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.024"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1990"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1533"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/biology3020426"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2217\/epi.13.43"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt356"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1271-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002228"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-1-r10"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1101\/gr.104695.109"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4161\/epi.25501"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2815-7"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25786"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00323.x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.04.018"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1101\/gr.147942.112"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.9.8756585"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.1.44"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10785"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1186\/ar2046"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/ar2616"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4742"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i1.10"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3249"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1002\/art.37722"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282574"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047930"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib20197f"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.12.001"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2014-x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.138"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201345"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3250-7"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059494"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.026"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu779"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20533"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu704"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1086\/302929"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn653"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr917"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn276"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1101\/gr.197194.115"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3130"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013444"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609509200"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0582"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3228"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1159\/000336193"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12190"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1159\/000059342"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210264"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.048975"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010693"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00369-6"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408795200"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505815200"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505820200"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.04.006"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2014.21.4.233"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq419"}],"container-title":["International Journal of Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2018\/6407257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2018\/6407257.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijg\/2018\/6407257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T19:31:15Z","timestamp":1533670275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijg\/2018\/6407257\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":80,"alternative-id":["6407257","6407257"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6407257","relation":{},"ISSN":["2314-436X","2314-4378"],"issn-type":[{"value":"2314-436X","type":"print"},{"value":"2314-4378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]}}}