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Notably, skeletal muscle atrophy is a consistent feature affecting the quality of life and prognosis. To date, limited therapeutic options are available, and research in the field is hampered by the lack of satisfactory models to study the complexity of wasting in cachexia\u2010inducing tumors, such as pancreatic cancer. Moreover, currently used <jats:italic>in vivo<\/jats:italic> models are characterized by an explosive cachexia with a lethal wasting within few days, while pancreatic cancer patients might experience alterations long before the onset of overt wasting. In this work, we established and characterized a slow\u2010paced model of pancreatic cancer\u2010induced muscle wasting that promotes efficient muscular wasting <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Treatment with conditioned media from pancreatic cancer cells led to the induction of atrophy <jats:italic>in vitro<\/jats:italic>, while tumor\u2010bearing mice presented a clear reduction in muscle mass and functionality. Intriguingly, several metabolic alterations in tumor\u2010bearing mice were identified, paving the way for therapeutic interventions with drugs targeting metabolism.<\/jats:p>","DOI":"10.1155\/2018\/6419805","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T23:35:36Z","timestamp":1519688136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolic Alterations in a Slow\u2010Paced Model of Pancreatic Cancer\u2010Induced Wasting"],"prefix":"10.1155","volume":"2018","author":[{"given":"Elisabeth","family":"Wyart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Reano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam 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