{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:30:04Z","timestamp":1781951404423,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Various pain management strategies for patients undergoing open excisional hemorrhoidectomy have been proposed, yet postoperative pain remains a frequent complaint. <jats:italic>Objective<\/jats:italic>. To determine whether mesoglycan (30\u2009mg two vials i.m. once\/day for the first 5 days postoperative, followed by 50\u2009mg 1 oral tablet twice\/day for 30 days) would reduce the edema of the mucocutaneous bridges and thus improve postoperative pain symptoms. <jats:italic>Patients and Methods<\/jats:italic>. For this prospective observational multicenter study, 101 patients undergoing excisional diathermy hemorrhoidectomy for III-IV degree hemorrhoidal disease were enrolled at 5 colorectal referral centers. Patients were assigned to receive either mesoglycan (study group SG) or a recommended oral dose of ketorolac tromethamine of 10\u2009mg every 4\u20136 hours, not exceeding 40\u2009mg per day and not exceeding 5 postoperative days according to the indications for short-term management of moderate\/severe acute postoperative pain, plus stool softeners (control group CG). <jats:italic>Results<\/jats:italic>. Postoperative thrombosis (SG 1\/48 versus CG 5\/45) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and pain after rectal examination (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) were significantly reduced at 7\u201310 days after surgery in the mesoglycan-treated group, permitting a faster return to work (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>); however, in the same group, the incidence of postoperative bleeding, considered relevant when needing a readmission or an unexpected outpatient visit, was higher, possibly owing to the drug\u2019s antithrombotic properties. <jats:italic>Conclusions<\/jats:italic>. The administration of mesoglycan after an open diathermy excisional hemorrhoidectomy can reduce postoperative thrombosis and pain at 7\u201310 days after surgery, permitting a faster return to normal activities.<\/jats:p>","DOI":"10.1155\/2018\/6423895","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T19:32:26Z","timestamp":1521487946000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-4671","authenticated-orcid":true,"given":"Gaetano","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy"},{"name":"Department of Surgical and Medical Sciences, University \u201cMagna Graecia\u201d of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Mistrangelo","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Citt\u00e0 della Salute e della Scienza Hospital, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Passera","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Citt\u00e0 della Salute e della Scienza Hospital, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Citt\u00e0 della Salute e della Scienza Hospital, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pozzo","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit, Department of Surgery, Infermi Hospital, Biella, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Perinotti","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit, Department of Surgery, Infermi Hospital, Biella, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Lanati","sequence":"additional","affiliation":[{"name":"Department of Surgery, Savigliano Hospital, Savigliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivano","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Savigliano Hospital, Savigliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tonello","sequence":"additional","affiliation":[{"name":"Department of Surgery, Koelliker Hospital, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Ugliono","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Citt\u00e0 della Salute e della Scienza Hospital, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences, University \u201cMagna Graecia\u201d of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Realis Luc","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Clerico","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Trompetto","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.07.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02628.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.16976"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13280"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9913"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1371-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3737-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7161"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-2022-8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3419-z"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.04.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-009-0549-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09003-X"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2015.3926\/2015"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.01.013"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3344-6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3749-x"},{"issue":"5","key":"18","first-page":"612","volume":"18","year":"2014","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2124-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1895-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.06.005"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318232d4c1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1216-6"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-009-0534-y"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/390643"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.10.007"},{"issue":"4","key":"27","first-page":"398","volume":"34","year":"2015","journal-title":"International Angiology"},{"issue":"1","key":"28","first-page":"21","volume":"45","year":"2009","journal-title":"European Journal of Physical and Rehabilitation Medicine"},{"issue":"6","key":"29","first-page":"741","volume":"55","year":"2007","journal-title":"Minerva Cardioangiologica"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1478"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31803-7"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31828b282c"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0677-0"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.04.012"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819c98a7"},{"issue":"1","key":"37","first-page":"77","volume":"57","year":"2005","journal-title":"Chirurgia Italiana"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0179-5"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0119-1"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2483-4"},{"issue":"41","key":"41","first-page":"1909","volume":"77","year":"1986","journal-title":"Minerva Medica"},{"issue":"2","key":"42","first-page":"311","volume":"31","year":"1985","journal-title":"Minerva Dietologica e Gastroenterologica"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2018\/6423895.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2018\/6423895.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2018\/6423895.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T19:32:51Z","timestamp":1521487971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2018\/6423895\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":41,"alternative-id":["6423895","6423895"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6423895","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}