{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:08:16Z","timestamp":1767848896256,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:00:00Z","timestamp":1524355200000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the effectiveness of acupuncture combined with auricular acupressure in chloasma treatment. <jats:italic>Methods<\/jats:italic>. A prospective, randomized controlled assessor\u2010blind clinical trial was performed and 135 patients were assigned into acupuncture combined with auricular acupressure (A), acupuncture (B), and control (C) groups, each with 45 patients. For groups A and B, body and facial acupuncture were applied for 2 months. For group A, auricular acupressure was applied concomitantly. For group C, vitamins C and E were prescribed for 3 months. Primary outcome measure was the therapeutic effects while secondary outcome measure was safety evaluation. <jats:italic>Results<\/jats:italic>. The total effective rate was 95.6%, 91.1%, and 75.6% for groups A, B, and C (<jats:italic>P<\/jats:italic> &lt; 0.01 between groups A and C; <jats:italic>P<\/jats:italic> &lt; 0.05 between groups B and C). The posttreatment estradiol (E<jats:sub>2<\/jats:sub>) levels in groups A and B were significantly decreased while the progesterone (P<jats:sub>4<\/jats:sub>) levels were significantly increased compared to pretreatment (<jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> &lt; 0.05, resp.). The differences were significant compared to group C (<jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> &lt; 0.05, resp.). No adverse events occurred. <jats:italic>Conclusion<\/jats:italic>. Acupuncture combined with auricular acupressure could significantly increase the therapeutic effect of chloasma treatment and could be better than vitamins C and E.<\/jats:p>","DOI":"10.1155\/2018\/6438458","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T23:32:55Z","timestamp":1524439975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Acupuncture Combined with Auricular Acupressure in the Treatment of Chloasma"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-914X","authenticated-orcid":false,"given":"Xing","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-1689","authenticated-orcid":false,"given":"Yu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,22]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"1","article-title":"Dermatology","author":"Zhang X. 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