{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:47:36Z","timestamp":1788965256272,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774422"],"award-info":[{"award-number":["81774422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The protective effect of electroacupuncture (EA) at Zusanli points (ST36) on myocardial injury in a model of sepsis was observed. Forty\u2010eight male Sprague\u2010Daley rats were subjected to sepsis by cecal ligation and puncture (CLP) and randomly divided into 4 groups (n=12; A: sepsis + EA; B: sepsis + sham acupuncture; C: sepsis + vagotomy; D: sepsis + vagotomy + EA). Bilateral points were stimulated (2mA, 2\u2010100 Hz) for 1 hour. Abdominal vagotomy was performed in groups C and D. At 6h after CLP, the plasma activity of creatine kinase\u2010MB (CK\u2010MB) was determined. A part of cardiac muscle was harvested for evaluating levels of tumor necrosis factor (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), nitric oxide (NO), myeloperoxidase (MPO), and the rate of water content. The activities of CK\u2010MB, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , NO, and MPO and the rate of water content in group A were significantly lower than those of the other groups 6h after CLP. EA after vagotomy showed less anti\u2010inflammatory and protective effects. The results indicated that EA obviously reduced the increased levels of the proinflammatory factors at 6h after CLP, and vagotomy could weaken or eliminate the effects of EA. Cholinergic anti\u2010inflammatory pathway is one of the main mechanisms of cardioprotective effect of EA.\n                  <\/jats:p>","DOI":"10.1155\/2018\/6509650","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T19:47:40Z","timestamp":1539028060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-5767","authenticated-orcid":false,"given":"Lijian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-6609","authenticated-orcid":false,"given":"Xian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-7935","authenticated-orcid":false,"given":"Sen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-3521","authenticated-orcid":false,"given":"Daniela","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-7108","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-0130","authenticated-orcid":false,"given":"Gerhard","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"296","article-title":"International guidelines on severe sepsis and septic shock treatment 2012","volume":"25","author":"Gao G.","year":"2013","journal-title":"Chinese Critical Care Medicine"},{"key":"e_1_2_11_2_2","first-page":"1001","article-title":"Prognostic value of a change in troponin-I? levels in patients with sepsis-associated myocardial dysfunction","volume":"46","author":"Xia J. 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